5UUK
Human Bfl-1 in complex with a Bfl-1-specific selected peptide
Summary for 5UUK
Entry DOI | 10.2210/pdb5uuk/pdb |
Related | 5UUL 5UUM 5UUP |
Descriptor | Bcl-2-related protein A1, Bfl-1-specific selected peptide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | apoptosis regulatory proteins, peptide library, protein binding, protein structure, proto-oncogene, specificity, bcl2a1, bcl2 related protein a1, peptide inhibitor, apoptosis |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 20286.97 |
Authors | Jenson, J.M.,Grant, R.A.,Keating, A.E. (deposition date: 2017-02-17, release date: 2017-06-21, Last modification date: 2023-10-04) |
Primary citation | Jenson, J.M.,Ryan, J.A.,Grant, R.A.,Letai, A.,Keating, A.E. Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife, 6:-, 2017 Cited by PubMed: 28594323DOI: 10.7554/eLife.25541 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.199 Å) |
Structure validation
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