5TXR

Structure of ALAS from S. cerevisiae non-covalently bound to PLP cofactor

Summary for 5TXR

• Entry DOI: 10.2210/pdb5txr/pdb
• Related: 5TXT
• Descriptor: 5-aminolevulinate synthase, mitochondrial, FORMIC ACID, PYRIDOXAL-5'-PHOSPHATE, ... (6 entities in total)
• Functional Keywords: transferase, heme biosynthesis, 5-aminolevulinic acid, pyridoxal 5-phosphate
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Total number of polymer chains: 2
• Total formula weight: 109025.95

Authors

Brown, B.L.,Grant, R.A.,Kardon, J.R.,Sauer, R.T.,Baker, T.A. (deposition date: 2016-11-17, release date: 2018-03-28, Last modification date: 2024-04-03)

• Primary citation: Brown, B.L.,Kardon, J.R.,Sauer, R.T.,Baker, T.A.; Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme.; Structure, 26:580-589.e4, 2018; PubMed: 29551290; DOI: 10.1016/j.str.2018.02.012

Experimental method

X-RAY DIFFRACTION (1.9 Å)