5UUL

Human Bfl-1 in complex with PUMA BH3

Summary for 5UUL

• Entry DOI: 10.2210/pdb5uul/pdb
• Related: 5UUK 5UUM 5UUP
• Descriptor: Bcl-2-related protein A1, Bcl-2-binding component 3, SULFATE ION, ... (4 entities in total)
• Functional Keywords: apoptosis regulatory proteins, protein binding, protein structure, proto-oncogene, bcl2a1, bcl2 related protein a1, apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 20358.10

Authors

Jenson, J.M.,Grant, R.A.,Keating, A.E. (deposition date: 2017-02-17, release date: 2017-06-21, Last modification date: 2023-10-04)

• Primary citation: Jenson, J.M.,Ryan, J.A.,Grant, R.A.,Letai, A.,Keating, A.E.; Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.; Elife, 6:-, 2017; PubMed: 28594323; DOI: 10.7554/eLife.25541

Experimental method

X-RAY DIFFRACTION (1.33 Å)