5W8F

Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14

Summary for 5W8F

• Entry DOI: 10.2210/pdb5w8f/pdb
• Related: 5W89
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide SAH-MS1-14, ZINC ION, ... (4 entities in total)
• Functional Keywords: stapled peptide, bcl-2 family, bh3 domain, apoptosis, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane ; Single-pass membrane protein : Q07820
• Total number of polymer chains: 2
• Total formula weight: 19874.43

Authors

Rezaei Araghi, R.,Jenson, J.M.,Grant, R.A.,Keating, A.E. (deposition date: 2017-06-21, release date: 2018-01-17, Last modification date: 2023-11-15)

• Primary citation: Rezaei Araghi, R.,Bird, G.H.,Ryan, J.A.,Jenson, J.M.,Godes, M.,Pritz, J.R.,Grant, R.A.,Letai, A.,Walensky, L.D.,Keating, A.E.; Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.; Proc. Natl. Acad. Sci. U.S.A., 115:E886-E895, 2018; PubMed: 29339518; DOI: 10.1073/pnas.1712952115

Experimental method

X-RAY DIFFRACTION (1.85 Å)