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5W89

Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18

Summary for 5W89
Entry DOI10.2210/pdb5w89/pdb
Related5W8F
DescriptorInduced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide SAH-MS1-18, ZINC ION, ... (4 entities in total)
Functional Keywordsstapled peptide, bcl-2 family, bh3 domain, apoptosis, peptide binding protein
Biological sourceHomo sapiens (Human)
More
Cellular locationMembrane ; Single-pass membrane protein : Q07820
Total number of polymer chains2
Total formula weight19878.46
Authors
Rezaei Araghi, R.,Jenson, J.M.,Grant, R.A.,Keating, A.E. (deposition date: 2017-06-21, release date: 2018-01-17, Last modification date: 2023-11-15)
Primary citationRezaei Araghi, R.,Bird, G.H.,Ryan, J.A.,Jenson, J.M.,Godes, M.,Pritz, J.R.,Grant, R.A.,Letai, A.,Walensky, L.D.,Keating, A.E.
Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115:E886-E895, 2018
Cited by
PubMed: 29339518
DOI: 10.1073/pnas.1712952115
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.42 Å)
Structure validation

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