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PDB: 117 件
6PXI
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BU of 6pxi by Molmil
The crystal structure of a singly capped HslUV complex with an axial pore plug and a HslU E257Q mutation
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, ATP-dependent protease subunit HslV, ...
著者Baytshtok, V, Grant, R.A, Sauer, R.T.
登録日2019-07-26
公開日2020-07-29
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (3.447 Å)
主引用文献Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug.
Cell Rep, 34, 2021
3HE5
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BU of 3he5 by Molmil
Heterospecific coiled-coil pair SYNZIP2:SYNZIP1
分子名称: SYNZIP1, SYNZIP2
著者Reinke, A.W, Grant, R.A, Keating, A.E.
登録日2009-05-07
公開日2010-03-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering.
J.Am.Chem.Soc., 132, 2010
3HE4
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BU of 3he4 by Molmil
Heterospecific coiled-coil pair SYNZIP5:SYNZIP6
分子名称: SYNZIP5, SYNZIP6
著者Reinke, A.W, Grant, R.A, Keating, A.E.
登録日2009-05-07
公開日2010-03-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering.
J.Am.Chem.Soc., 132, 2010
6UA3
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BU of 6ua3 by Molmil
Human Mcl-1 in complex with a modified Bim BH3 peptide
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, modified Bim BH3 peptide
著者Mandal, T, Grant, R.A, Keating, A.E.
登録日2019-09-10
公開日2020-09-16
実験手法X-RAY DIFFRACTION (1.552 Å)
主引用文献Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
To Be Published
6UAB
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BU of 6uab by Molmil
Human Mcl-1 in complex with a modified unnatural Bim BH3 peptide
分子名称: ADAMANTANE, Induced myeloid leukemia cell differentiation protein Mcl-1, modified unnatural Bim BH3 peptide
著者Mandal, T, Grant, R.A, Keating, A.E.
登録日2019-09-10
公開日2020-09-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inhibitor peptides against Mcl-1 containing non-natural amino acids show potent apoptotic response.
To Be Published
6CZF
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BU of 6czf by Molmil
The structure of E. coli PurF in complex with ppGpp-Mg
分子名称: Amidophosphoribosyltransferase, GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION
著者Wang, B, Grant, R.A, Laub, M.T.
登録日2018-04-09
公開日2018-10-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Affinity-based capture and identification of protein effectors of the growth regulator ppGpp.
Nat. Chem. Biol., 15, 2019
3KJ0
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BU of 3kj0 by Molmil
Mcl-1 in complex with Bim BH3 mutant I2dY
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1
著者Fire, E, Grant, R.A, Keating, A.E.
登録日2009-11-02
公開日2010-02-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
3KJ1
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BU of 3kj1 by Molmil
Mcl-1 in complex with Bim BH3 mutant I2dA
分子名称: ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ...
著者Fire, E, Grant, R.A, Keating, A.E.
登録日2009-11-02
公開日2010-02-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.945 Å)
主引用文献Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
3KJ2
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BU of 3kj2 by Molmil
Mcl-1 in complex with Bim BH3 mutant F4aE
分子名称: ACETATE ION, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ...
著者Fire, E, Grant, R.A, Keating, A.E.
登録日2009-11-02
公開日2010-02-16
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.351 Å)
主引用文献Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
Protein Sci., 19, 2010
7LXE
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BU of 7lxe by Molmil
ENAH EVH1 domain bound to peptide from ABI1
分子名称: Protein enabled homolog,Abl interactor 1
著者Keating, A.E, Grant, R.A, Hwang, T.H.
登録日2021-03-03
公開日2022-01-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH.
Elife, 11, 2022
5W89
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BU of 5w89 by Molmil
Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18
著者Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E.
登録日2017-06-21
公開日2018-01-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5UUM
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BU of 5uum by Molmil
Human Mcl-1 in complex with a Bfl-1-specific selected peptide
分子名称: Bfl-1 specific peptide FS2, Induced myeloid leukemia cell differentiation protein Mcl-1, SULFATE ION, ...
著者Jenson, J.M, Grant, R.A, Keating, A.E.
登録日2017-02-17
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.346 Å)
主引用文献Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Elife, 6, 2017
5UUL
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BU of 5uul by Molmil
Human Bfl-1 in complex with PUMA BH3
分子名称: Bcl-2-binding component 3, Bcl-2-related protein A1, SULFATE ION
著者Jenson, J.M, Grant, R.A, Keating, A.E.
登録日2017-02-17
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Elife, 6, 2017
5UUK
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BU of 5uuk by Molmil
Human Bfl-1 in complex with a Bfl-1-specific selected peptide
分子名称: Bcl-2-related protein A1, Bfl-1-specific selected peptide, SULFATE ION
著者Jenson, J.M, Grant, R.A, Keating, A.E.
登録日2017-02-17
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.199 Å)
主引用文献Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Elife, 6, 2017
5UUP
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BU of 5uup by Molmil
Human Bfl-1 covalently cross-linked to an electrophilic variant of a Bfl-1-specific selected peptide
分子名称: Bcl-2-related protein A1, Bfl-1-specific selected peptide, SULFATE ION
著者Jenson, J.M, Grant, R.A, Keating, A.E.
登録日2017-02-17
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.726 Å)
主引用文献Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Elife, 6, 2017
5TXR
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BU of 5txr by Molmil
Structure of ALAS from S. cerevisiae non-covalently bound to PLP cofactor
分子名称: 5-aminolevulinate synthase, mitochondrial, FORMIC ACID, ...
著者Brown, B.L, Grant, R.A, Kardon, J.R, Sauer, R.T, Baker, T.A.
登録日2016-11-17
公開日2018-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme.
Structure, 26, 2018
5TXT
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BU of 5txt by Molmil
Structure of asymmetric apo/holo ALAS dimer from S. cerevisiae
分子名称: 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, 5-aminolevulinate synthase, mitochondrial, ...
著者Brown, B.L, Grant, R.A, Kardon, J.R, Sauer, R.T, Baker, T.A.
登録日2016-11-17
公開日2018-03-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme.
Structure, 26, 2018

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件を2024-10-09に公開中

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