5X5B
 
 | | Prefusion structure of SARS-CoV spike glycoprotein, conformation 2 | | 分子名称: | Spike glycoprotein | | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | 登録日 | 2017-02-15 | | 公開日 | 2017-05-03 | | 最終更新日 | 2017-05-24 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5X5C
 | | Prefusion structure of MERS-CoV spike glycoprotein, conformation 1 | | 分子名称: | S protein | | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | 登録日 | 2017-02-15 | | 公開日 | 2017-05-03 | | 最終更新日 | 2017-05-24 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5F1N
 | | MHC complexed to 11mer peptide | | 分子名称: | Beta-2-microglobulin, MHC class I antigen, Peptide from Cytochrome P450 family 1 subfamily B polypeptide 1 | | 著者 | Liu, J, Chai, Y, Qi, J, Gao, G.F. | | 登録日 | 2015-11-30 | | 公開日 | 2016-11-30 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I
J Immunol., 197, 2016
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5X5V
 | | Crystal structure of pseudorabies virus glycoprotein D | | 分子名称: | GD | | 著者 | Li, A, Lu, G, Qi, J, Wu, L, Tian, K, Luo, T, Shi, Y, Yan, J, Gao, G.F. | | 登録日 | 2017-02-17 | | 公開日 | 2017-04-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of pseudorabies virus glycoprotein D
To Be Published
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5X5F
 | | Prefusion structure of MERS-CoV spike glycoprotein, conformation 2 | | 分子名称: | S protein | | 著者 | Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F. | | 登録日 | 2017-02-15 | | 公開日 | 2017-05-03 | | 最終更新日 | 2017-05-24 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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5GSX
 | | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 142-2 | | 分子名称: | 10-mer peptide from Spike protein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | | 登録日 | 2016-08-17 | | 公開日 | 2017-06-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
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5GSR
 | | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide I5A | | 分子名称: | 9-mer peptide from Spike protein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | | 登録日 | 2016-08-17 | | 公開日 | 2017-04-26 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC.
J. Immunol., 198, 2017
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5HGD
 | | HLA*A2402 complexed with HIV nef138 Y2F mutant 10mer epitope | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | | 著者 | Shi, Y, Qi, J, Gao, G.F. | | 登録日 | 2016-01-08 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation.
Cell Rep, 15, 2016
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5HGA
 | | HLA*A2402 complex with HIV nef138 Y2F-8mer mutant epitope | | 分子名称: | 8-mer from Protein Nef, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | 著者 | Shi, Y, Qi, J, Gao, G.F. | | 登録日 | 2016-01-08 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | | 主引用文献 | Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation.
Cell Rep, 15, 2016
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6J14
 | | Complex structure of GY-14 and PD-1 | | 分子名称: | GY-14 heavy chain V fragment, GY-14 light chain V fragment, Programmed cell death protein 1 | | 著者 | Chen, D, Tan, S, Whang, H, Zhang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. | | 登録日 | 2018-12-27 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
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6J15
 | | Complex structure of GY-5 Fab and PD-1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GY-5 heavy chain Fab, ... | | 著者 | Chen, D, Tan, S, Zhang, H, Wang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F. | | 登録日 | 2018-12-27 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
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8GRY
 | | Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with rat ACE2 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1, ... | | 著者 | Zhao, Z.N, Xie, Y.F, Chai, Y, Qi, J.X, Gao, G.F. | | 登録日 | 2022-09-03 | | 公開日 | 2023-07-19 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Nat Commun, 14, 2023
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6KL9
 | | Structure of LbCas12a-crRNA complex bound to AcrVA4 (form A complex) | | 分子名称: | AcrVA4, LbCas12a, MAGNESIUM ION, ... | | 著者 | Peng, R, Li, Z, Xu, Y, He, S, Peng, Q, Shi, Y, Gao, G.F. | | 登録日 | 2019-07-30 | | 公開日 | 2019-09-11 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6KLB
 | | Structure of LbCas12a-crRNA complex bound to AcrVA4 (form B complex) | | 分子名称: | AcrVA4, LbCas12a, MAGNESIUM ION, ... | | 著者 | Peng, R, Li, Z, Xu, Y, He, S, Peng, Q, Shi, Y, Gao, G.F. | | 登録日 | 2019-07-30 | | 公開日 | 2019-09-11 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7YA1
 | | Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | | 登録日 | 2022-06-27 | | 公開日 | 2022-08-31 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Nat Commun, 13, 2022
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4K65
 | | Structure of an airborne transmissible avian influenza H5 hemagglutinin mutant from the influenza virus A/Indonesia/5/2005 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | 著者 | Zhang, W, Shi, Y, Lu, X, Shu, Y, Qi, J, Gao, G.F. | | 登録日 | 2013-04-15 | | 公開日 | 2013-05-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level.
Science, 340, 2013
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4FVK
 | | Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Li, Q, Sun, X.M, Li, Z.X, Liu, Y, Vavricka, C.J, Qi, J.X, Gao, G.F. | | 登録日 | 2012-06-29 | | 公開日 | 2012-09-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus
Proc.Natl.Acad.Sci.USA, 109, 2012
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4MX5
 | | Structure of ricin A chain bound with benzyl-(2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)ethyl)carbamate | | 分子名称: | Ricin A chain, benzyl (2-{[(2-amino-4-oxo-3,4-dihydropteridin-7-yl)carbonyl]amino}ethyl)carbamate | | 著者 | Jasheway, K.R, Robertus, J.D, Wiget, P.A, Manzano, L.A, Pruet, J.M, Gao, G, Saito, R, Monzingo, A.F, Anslyn, E.V. | | 登録日 | 2013-09-25 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Sulfur incorporation generally improves Ricin inhibition in pterin-appended glycine-phenylalanine dipeptide mimics.
Bioorg.Med.Chem.Lett., 23, 2013
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4H52
 | | Wild-type influenza N2 neuraminidase covalent complex with 3-fluoro-Neu5Ac | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, CALCIUM ION, ... | | 著者 | Vavricka, C.J, Liu, Y, Kiyota, H, Sriwilaijaroen, N, Qi, J, Tanaka, K, Wu, Y, Li, Q, Li, Y, Yan, J, Suzuki, Y, Gao, G.F. | | 登録日 | 2012-09-18 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors
Nat Commun, 4, 2013
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5X4R
 | | Structure of the N-terminal domain (NTD) of MERS-CoV spike protein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S protein | | 著者 | Yuan, Y, Zhang, Y, Qi, J, Shi, Y, Gao, G.F. | | 登録日 | 2017-02-14 | | 公開日 | 2017-05-03 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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4MX1
 | | Structure of ricin A chain bound with 2-amino-4-oxo-N-(2-(3-phenylureido)ethyl)-3,4-dihydropteridine-7-carboxamide | | 分子名称: | 2-amino-4-oxo-N-{2-[(phenylcarbamoyl)amino]ethyl}-3,4-dihydropteridine-7-carboxamide, MALONIC ACID, Ricin A chain, ... | | 著者 | Robertus, J.D, Wiget, P.A, Manzano, L.A, Pruet, J.M, Gao, G, Saito, R, Jasheway, K.R, Monzingo, A.F, Anslyn, E.V. | | 登録日 | 2013-09-25 | | 公開日 | 2014-01-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Sulfur incorporation generally improves Ricin inhibition in pterin-appended glycine-phenylalanine dipeptide mimics.
Bioorg.Med.Chem.Lett., 23, 2013
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5XJ3
 | | Complex structure of ipilimumab-scFv and CTLA-4 | | 分子名称: | Cytotoxic T-lymphocyte protein 4, ipilimumab-VH, ipilimumab-VL | | 著者 | He, M, Chai, Y, Qi, J, Tong, Z, Tan, S, Gao, G.F. | | 登録日 | 2017-04-29 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies
Oncotarget, 8, 2017
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4HX1
 | | Structure of HLA-A68 complexed with a tumor antigen derived peptide | | 分子名称: | 9-mer peptide from Tyrosinase-related protein-2, Beta-2-microglobulin, GLYCEROL, ... | | 著者 | Niu, L, Cheng, H, Zhang, S, Tan, S, Zhang, Y, Qi, J, Liu, J, Gao, G.F. | | 登録日 | 2012-11-09 | | 公開日 | 2013-10-02 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes
Mol.Immunol., 55, 2013
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5X4S
 | | Structure of the N-terminal domain (NTD)of SARS-CoV spike protein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Yuan, Y, Zhang, Y, Qi, J, Shi, Y, Gao, G.F. | | 登録日 | 2017-02-14 | | 公開日 | 2017-05-03 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
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4HZW
 | | Crystal structure of influenza A neuraminidase N3 complexed with laninamivir | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ... | | 著者 | Li, Q, Qi, J, Vavricka, C.J, Gao, G.F. | | 登録日 | 2012-11-15 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | | 主引用文献 | Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
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