4QN6

Crystal structure of Neuraminidase N6 complexed with Laninamivir

Summary for 4QN6

• Entry DOI: 10.2210/pdb4qn6/pdb
• Related: 4QN3 4QN4 4QN5 4QN7
• Descriptor: Neuraminidase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: 6-bladed beta-propeller, hydrolase, calcium binding, glycosylation
• Biological source: Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6))
• Cellular location: Virion membrane: Q2FCL6
• Total number of polymer chains: 2
• Total formula weight: 90481.25

Authors

Sun, X.,Li, Q.,Wu, Y.,Liu, Y.,Qi, J.,Vavricka, C.J.,Gao, G.F. (deposition date: 2014-06-17, release date: 2014-07-30, Last modification date: 2023-11-08)

• Primary citation: Sun, X.,Li, Q.,Wu, Y.,Wang, M.,Liu, Y.,Qi, J.,Vavricka, C.J.,Gao, G.F.; Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle.; J.Virol., 88:9197-9207, 2014; PubMed: 24899180; DOI: 10.1128/JVI.00805-14

Experimental method

X-RAY DIFFRACTION (1.945 Å)