5W50
| Crystal structure of the segment, LIIKGI, from the RRM2 of TDP-43, residues 248-253 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Trinh, H, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-06-13 | Release date: | 2018-02-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat. Struct. Mol. Biol., 25, 2018
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5W52
| MicroED structure of the segment, DLIIKGISVHI, from the RRM2 of TDP-43, residues 247-257 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-06-13 | Release date: | 2018-02-21 | Last modified: | 2024-04-03 | Method: | ELECTRON CRYSTALLOGRAPHY (1.4 Å) | Cite: | Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat. Struct. Mol. Biol., 25, 2018
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5WIA
| Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43, residues 370-375 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Trinh, H, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-18 | Release date: | 2018-04-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.002 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WKD
| Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Trinh, H, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-07-25 | Release date: | 2018-04-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WOR
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5WHN
| Crystal structure of the segment, NFGAFS, from the low complexity domain of TDP-43, residues 312-317 | Descriptor: | Segment of TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-17 | Release date: | 2018-04-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5W7V
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5WHP
| Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low complexity domain of TDP-43, residues 312-317 | Descriptor: | Segment of TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-17 | Release date: | 2018-05-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WIQ
| Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43, residues 396-402 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2017-07-19 | Release date: | 2018-04-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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5WKB
| MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 | Descriptor: | TAR DNA-binding protein 43 | Authors: | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | Deposit date: | 2017-07-24 | Release date: | 2018-05-23 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (1 Å) | Cite: | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat. Struct. Mol. Biol., 25, 2018
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7K3Y
| GGYAGAS segment 52-58 from Keratin-8 | Descriptor: | GGYAGAS segment 52-58 from the low complexity domain of Keratin-8 | Authors: | Murray, K.A, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2020-09-14 | Release date: | 2021-11-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat.Struct.Mol.Biol., 29, 2022
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7K3C
| SGMGGIT segment 58-64 from Keratin-8 | Descriptor: | ETHANOL, SGMGGIT segment 58-64 from the low complexity domain of Keratin-8, TRIETHYLENE GLYCOL | Authors: | Murray, K.A, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2020-09-11 | Release date: | 2021-11-10 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat.Struct.Mol.Biol., 29, 2022
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7K3X
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7LTU
| AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2, RESIDUES 217-222, CRYSTAL FORM 1 | Descriptor: | AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2,RESIDUES 217-222, trifluoroacetic acid | Authors: | Zee, C.-T, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S. | Deposit date: | 2021-02-20 | Release date: | 2021-03-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.122 Å) | Cite: | Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. Biorxiv, 2021
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7LUX
| AALALL segment from the Nucleoprotein of SARS-CoV-2, residues 217-222, crystal form 2 | Descriptor: | Nucleoprotein AALALL, TETRAETHYLENE GLYCOL | Authors: | Lu, J, Zee, C.-T, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S. | Deposit date: | 2021-02-23 | Release date: | 2021-03-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.303 Å) | Cite: | Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. Biorxiv, 2021
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7LUZ
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7LV2
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7M64
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M65
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M62
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M61
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 1 | Descriptor: | Islet amyloid polypeptide | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2021-03-25 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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6PES
| Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | Descriptor: | Alpha-synuclein | Authors: | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | Deposit date: | 2019-06-20 | Release date: | 2019-11-27 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
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6PIL
| Antibody scFv-M204 monomeric state | Descriptor: | CHLORIDE ION, scFv-M204 antibody | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | Deposit date: | 2019-06-26 | Release date: | 2020-06-24 | Last modified: | 2020-08-12 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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6PEO
| Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril | Descriptor: | Alpha-synuclein | Authors: | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | Deposit date: | 2019-06-20 | Release date: | 2019-11-27 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
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6PK8
| Antibody scFv-M204 dimeric state | Descriptor: | SULFATE ION, scFv-M204 antibody | Authors: | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | Deposit date: | 2019-06-28 | Release date: | 2020-06-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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