7K3X

SGMGCIT segment 58-64 from Keratin-8 with G62C mutation

Summary for 7K3X

• Entry DOI: 10.2210/pdb7k3x/pdb
• Related: 7K3C
• Descriptor: SGMGCIT segment 58-64 from Keratin-8 with G62C mutation, ISOPROPYL ALCOHOL (3 entities in total)
• Functional Keywords: amyloid filament, low complexity sequence, cryptogenic liver disease, protein fibril
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 727.89

Authors

Murray, K.A.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2020-09-14, release date: 2021-11-10, Last modification date: 2024-04-03)

• Primary citation: Murray, K.A.,Hughes, M.P.,Hu, C.J.,Sawaya, M.R.,Salwinski, L.,Pan, H.,French, S.W.,Seidler, P.M.,Eisenberg, D.S.; Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies.; Nat.Struct.Mol.Biol., 29:529-536, 2022; PubMed: 35637421; DOI: 10.1038/s41594-022-00774-y

Experimental method

X-RAY DIFFRACTION (1.705 Å)