7M64

Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3

Summary for 7M64

• Entry DOI: 10.2210/pdb7m64/pdb
• EMDB information: 23686 23687 23688 23689
• Descriptor: Islet amyloid polypeptide (1 entity in total)
• Functional Keywords: hiapp, type ii diabetes, amyloid, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 10
• Total formula weight: 39073.12

Authors

Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2021-03-25, release date: 2021-09-22)

• Primary citation: Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Abskharon, R.,Saelices, L.,Nguyen, B.A.,Lu, J.,Murray, K.A.,Kandeel, F.,Eisenberg, D.S.; Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores; Nat.Struct.Mol.Biol., 28:724-730, 2021; DOI: 10.1038/s41594-021-00646-x

Experimental method

ELECTRON MICROSCOPY (4 Å)