6PEO

Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril

Summary for 6PEO

• Entry DOI: 10.2210/pdb6peo/pdb
• EMDB information: 20328
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: alpha-synuclein, amyloid, h50q, hereditary mutation, fibril, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 5
• Total formula weight: 72330.46

Authors

Boyer, D.R.,Li, B.,Sawaya, M.R.,Jiang, L.,Eisenberg, D.S. (deposition date: 2019-06-20, release date: 2019-11-27, Last modification date: 2024-03-20)

• Primary citation: Boyer, D.R.,Li, B.,Sun, C.,Fan, W.,Sawaya, M.R.,Jiang, L.,Eisenberg, D.S.; Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.; Nat.Struct.Mol.Biol., 26:1044-1052, 2019; PubMed: 31695184; DOI: 10.1038/s41594-019-0322-y

Experimental method

ELECTRON MICROSCOPY (3.3 Å)