8FRR
 
 | | Wild-type myocilin olfactomedin domain | | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | | 著者 | Ma, M.T, Lieberman, R.L, Huard, D.J.E. | | 登録日 | 2023-01-08 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming beta-propeller.
Nat Commun, 15, 2024
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6HIZ
 | | Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the head of the small mitoribosomal subunit | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (143-MER), ... | | 著者 | Ramrath, D.J.F, Niemann, M, Leibundgut, M, Bieri, P, Prange, C, Horn, E.K, Leitner, A, Boehringer, A, Schneider, A, Ban, N. | | 登録日 | 2018-08-31 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Science, 362, 2018
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5NBU
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1YIV
 | | Structure of myelin P2 protein from Equine spinal cord | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, LAURYL DIMETHYLAMINE-N-OXIDE, Myelin P2 protein | | 著者 | Hunter, D.J.B, MacMaster, R, Rozak, A.W, Riboldi-Tunnicliffe, A, Grifiths, I.R, Freer, A.A. | | 登録日 | 2005-01-13 | | 公開日 | 2005-07-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of myelin P2 protein from equine spinal cord.
Acta Crystallogr.,Sect.D, 61, 2005
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3KCG
 | | Crystal structure of the antithrombin-factor IXa-pentasaccharide complex | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, Antithrombin-III, ... | | 著者 | Huntington, J.A, Johnson, D.J.D. | | 登録日 | 2009-10-21 | | 公開日 | 2010-02-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3ZTG
 | | Solution structure of the RING finger-like domain of Retinoblastoma Binding Protein-6 (RBBP6) | | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE RBBP6, ZINC ION | | 著者 | Kappo, M.A, Ab, E, Atkinson, R.A, Faro, A, Muleya, V, Mulaudzi, T, Poole, J.O, McKenzie, J.M, Pugh, D.J.R. | | 登録日 | 2011-07-07 | | 公開日 | 2011-12-07 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the Ring Finger-Like Domain of Retinoblastoma Binding Protein-6 (Rbbp6) Suggests It Functions as a U-Box
J.Biol.Chem., 287, 2012
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4AEJ
 | | Crystal structure of Human fibrillar procollagen type III C- propeptide trimer | | 分子名称: | CALCIUM ION, COLLAGEN ALPHA-1(III) CHAIN, GLYCEROL | | 著者 | Bourhis, J.M, Mariano, N, Zhao, Y, Harlos, K, Jones, E.Y, Moali, C, Aghajari, N, Hulmes, D.J.S. | | 登録日 | 2012-01-11 | | 公開日 | 2012-09-12 | | 最終更新日 | 2019-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structural Basis of Fibrillar Collagen Trimerization and Related Genetic Disorders.
Nat.Struct.Mol.Biol., 19, 2012
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7BER
 | | SFX structure of the MyD88 TIR domain higher-order assembly (solved, rebuilt and refined using an identical protocol to the MicroED structure of the MyD88 TIR domain higher-order assembly) | | 分子名称: | Myeloid differentiation primary response protein MyD88 | | 著者 | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | 登録日 | 2020-12-24 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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7BEQ
 | | MicroED structure of the MyD88 TIR domain higher-order assembly | | 分子名称: | Myeloid differentiation primary response protein MyD88 | | 著者 | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | 登録日 | 2020-12-24 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3 Å) | | 主引用文献 | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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2KZD
 | | Structure of a (3+1) G-quadruplex formed by hTERT promoter sequence | | 分子名称: | DNA (5'-D(*AP*GP*GP*GP*IP*AP*GP*GP*GP*GP*CP*TP*GP*GP*GP*AP*GP*GP*GP*C)-3') | | 著者 | Lim, K.W, Lacroix, L, Yue, D.J.E, Lim, J.K.C, Lim, J.M.W, Phan, A.T. | | 登録日 | 2010-06-16 | | 公開日 | 2010-10-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Coexistence of two distinct G-quadruplex conformations in the hTERT promoter
J.Am.Chem.Soc., 132, 2010
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2KZE
 | | Structure of an all-parallel-stranded G-quadruplex formed by hTERT promoter sequence | | 分子名称: | DNA (5'-D(*AP*IP*GP*GP*GP*AP*GP*GP*GP*IP*CP*TP*GP*GP*GP*AP*GP*GP*GP*C)-3') | | 著者 | Lim, K.W, Lacroix, L, Yue, D.J.E, Lim, J.K.C, Lim, J.M.W, Phan, A.T. | | 登録日 | 2010-06-16 | | 公開日 | 2010-10-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Coexistence of two distinct G-quadruplex conformations in the hTERT promoter
J.Am.Chem.Soc., 132, 2010
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5J8H
 | | Structure of calmodulin in a complex with a peptide derived from a calmodulin-dependent kinase | | 分子名称: | CALCIUM ION, Calmodulin, Eukaryotic elongation factor 2 kinase | | 著者 | Alphonse, S, Lee, K, Piserchio, A, Tavares, C.D.J, Giles, D.H, Wellmann, R.M, Dalby, K.N, Ghose, R. | | 登録日 | 2016-04-07 | | 公開日 | 2016-09-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.
Structure, 24, 2016
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4PHQ
 | | ClyA CC6/264 ox (6-303) | | 分子名称: | ACETATE ION, GLYCEROL, Hemolysin E, ... | | 著者 | Roderer, D.J.A, Glockshuber, R, Ban, N. | | 登録日 | 2014-05-06 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Characterization of Variants of the Pore-Forming Toxin ClyA from Escherichia coli Controlled by a Redox Switch.
Biochemistry, 53, 2014
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5K31
 | | Crystal structure of Human fibrillar procollagen type I C-propeptide Homo-trimer | | 分子名称: | CALCIUM ION, CHLORIDE ION, Collagen alpha-1(I) chain, ... | | 著者 | Sharma, U, Hulmes, D.J.S, Aghajari, N. | | 登録日 | 2016-05-19 | | 公開日 | 2017-03-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis of homo- and heterotrimerization of collagen I.
Nat Commun, 8, 2017
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5IN9
 | | Crystal structure of Grp94 bound to methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, an inhibitor based on the BnIm and Radamide scaffolds. | | 分子名称: | Endoplasmin, GLYCEROL, TRIETHYLENE GLYCOL, ... | | 著者 | Lieberman, R.L, Huard, D.J.E, Kizziah, J.L. | | 登録日 | 2016-03-07 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.
J.Med.Chem., 59, 2016
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4OGW
 | | Structure of a human CD38 mutant complexed with NMN | | 分子名称: | ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE | | 著者 | Shewchuk, L.M, Preugschat, F, Carter, L.H, Boros, E.E, Moyer, M.B, Stewart, E.L, Porter, D.J.T. | | 登録日 | 2014-01-16 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157.
Arch.Biochem.Biophys., 564C, 2014
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4PHO
 | | ClyA CC6/264 ox (2-303) | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Hemolysin E, ... | | 著者 | Roderer, D.J.A, Glockshuber, R, Ban, N. | | 登録日 | 2014-05-06 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.123 Å) | | 主引用文献 | Characterization of Variants of the Pore-Forming Toxin ClyA from Escherichia coli Controlled by a Redox Switch.
Biochemistry, 53, 2014
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2KRG
 | | Solution Structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) | | 分子名称: | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | | 著者 | Bhattacharya, S, Dai, Z, Li, J, Baxter, S, Callaway, D.J.E, Cowburn, D, Bu, Z. | | 登録日 | 2009-12-17 | | 公開日 | 2009-12-29 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
J.Biol.Chem., 285, 2010
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6RQF
 | | 3.6 Angstrom cryo-EM structure of the dimeric cytochrome b6f complex from Spinacia oleracea with natively bound thylakoid lipids and plastoquinone molecules | | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | | 著者 | Malone, L.A, Qian, P, Mayneord, G.E, Hitchcock, A, Farmer, D, Thompson, R, Swainsbury, D.J.K, Ranson, N, Hunter, C.N, Johnson, M.P. | | 登録日 | 2019-05-15 | | 公開日 | 2019-11-13 | | 最終更新日 | 2019-12-04 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Cryo-EM structure of the spinach cytochrome b6f complex at 3.6 angstrom resolution.
Nature, 575, 2019
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6AOL
 | | Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 3-chloro-2-(2-{2-[(4-fluorophenyl)methyl]phenyl}ethyl)-4,6-dihydroxybenzoate | | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Endoplasmin, methyl 3-chloro-2-(2-{2-[(4-fluorophenyl)methyl]phenyl}ethyl)-4,6-dihydroxybenzoate | | 著者 | Lieberman, R.L, Huard, D.J.E. | | 登録日 | 2017-08-16 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.764 Å) | | 主引用文献 | Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.
Chemistry, 23, 2017
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6ASQ
 | | Structure of Grp94 bound to methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, a pan-Hsp90 inhibitor | | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, Endoplasmin, ... | | 著者 | Huard, D.J.E, Lieberman, R.L. | | 登録日 | 2017-08-25 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.
ACS Chem. Biol., 13, 2018
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6SG9
 | | Head domain of the mt-SSU assemblosome from Trypanosoma brucei | | 分子名称: | 9S rRNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N. | | 登録日 | 2019-08-03 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Science, 365, 2019
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6SGA
 | | Body domain of the mt-SSU assemblosome from Trypanosoma brucei | | 分子名称: | 9S rRNA, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N. | | 登録日 | 2019-08-03 | | 公開日 | 2019-09-18 | | 最終更新日 | 2019-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Science, 365, 2019
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6SGB
 | | mt-SSU assemblosome of Trypanosoma brucei | | 分子名称: | 9S rRNA, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Saurer, M, Ramrath, D.J.F, Niemann, M, Calderaro, S, Prange, C, Mattei, S, Scaiola, A, Leitner, A, Bieri, P, Horn, E.K, Leibundgut, M, Boehringer, D, Schneider, A, Ban, N. | | 登録日 | 2019-08-03 | | 公開日 | 2019-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Science, 365, 2019
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6Z5S
 | | RC-LH1(14)-W complex from Rhodopseudomonas palustris | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, (6~{R},10~{S},14~{R},19~{R},23~{S},24~{E},27~{S},28~{E})-2,6,10,14,19,23,27,31-octamethyldotriaconta-24,28-dien-2-ol, ... | | 著者 | Swainsbury, D.J.K, Qian, P, Hitchcock, A, Hunter, C.N. | | 登録日 | 2020-05-27 | | 公開日 | 2021-01-13 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | Structures of Rhodopseudomonas palustris RC-LH1 complexes with open or closed quinone channels.
Sci Adv, 7, 2021
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