7BV1
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![BU of 7bv1 by Molmil](/molmil-images/mine/7bv1) | Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | 著者 | Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. | 登録日 | 2020-04-09 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
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7BV2
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![BU of 7bv2 by Molmil](/molmil-images/mine/7bv2) | The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP) | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Yin, W, Mao, C, Luan, X, Shen, D, Shen, Q, Su, H, Wang, X, Zhou, F, Zhao, W, Gao, M, Chang, S, Xie, Y.C, Tian, G, Jiang, H.W, Tao, S.C, Shen, J, Jiang, Y, Jiang, H, Xu, Y, Zhang, S, Zhang, Y, Xu, H.E. | 登録日 | 2020-04-09 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science, 368, 2020
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6B7B
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![BU of 6b7b by Molmil](/molmil-images/mine/6b7b) | Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with 5-methoxy-2-methyl-1H-indole | 分子名称: | 5-methoxy-2-methyl-1H-indole, DIMETHYL SULFOXIDE, PYROPHOSPHATE 2-, ... | 著者 | Proudfoot, A.W, Bussiere, D, Lingel, A. | 登録日 | 2017-10-03 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.981 Å) | 主引用文献 | High-Confidence Protein-Ligand Complex Modeling by NMR-Guided Docking Enables Early Hit Optimization. J. Am. Chem. Soc., 139, 2017
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6BFY
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![BU of 6bfy by Molmil](/molmil-images/mine/6bfy) | Crystal structure of enolase from Escherichia coli with bound 2-phosphoglycerate substrate | 分子名称: | 2-PHOSPHOGLYCERIC ACID, Enolase, GLYCEROL, ... | 著者 | Erlandsen, H, Wright, D, Krucinska, J. | 登録日 | 2017-10-27 | 公開日 | 2018-10-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens. Biochemistry, 58, 2019
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6BHY
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![BU of 6bhy by Molmil](/molmil-images/mine/6bhy) | |
7A6U
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![BU of 7a6u by Molmil](/molmil-images/mine/7a6u) | Cryo-EM structure of the cytoplasmic domain of human TRPC6 | 分子名称: | Short transient receptor potential channel 6, UNKNOWN ATOM OR ION | 著者 | Grieben, M, Pike, A.C.W, Wang, D, Mukhopadhyay, S.M.M, Chalk, R, Marsden, B.D, Burgess-Brown, N.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2020-08-26 | 公開日 | 2020-09-30 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Cryo-EM structure of the cytoplasmic domain of human TRPC6 TO BE PUBLISHED
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8DQL
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![BU of 8dql by Molmil](/molmil-images/mine/8dql) | CryoEM structure of IglD | 分子名称: | Secretion system protein | 著者 | Liu, X, Clemens, D, Lee, B, Yang, X, Zhou, H, Horwitz, M. | 登録日 | 2022-07-19 | 公開日 | 2022-08-17 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System. Mbio, 13, 2022
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6BHQ
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![BU of 6bhq by Molmil](/molmil-images/mine/6bhq) | Mouse Immunoglobulin G 2c Fc fragment with complex-type glycan | 分子名称: | GLYCEROL, Igh protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Falconer, D, Barb, A. | 登録日 | 2017-10-31 | 公開日 | 2018-02-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Mouse IgG2c Fc loop residues promote greater receptor-binding affinity than mouse IgG2b or human IgG1. PLoS ONE, 13, 2018
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7XA3
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![BU of 7xa3 by Molmil](/molmil-images/mine/7xa3) | Cryo-EM structure of the CCL2 bound CCR2-Gi complex | 分子名称: | C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | 登録日 | 2022-03-17 | 公開日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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7X9Y
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![BU of 7x9y by Molmil](/molmil-images/mine/7x9y) | Cryo-EM structure of the apo CCR3-Gi complex | 分子名称: | C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | 登録日 | 2022-03-16 | 公開日 | 2022-08-24 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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8CNX
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![BU of 8cnx by Molmil](/molmil-images/mine/8cnx) | Structure of Enterovirus D68 3C protease | 分子名称: | Protease 3C | 著者 | Lithgo, R.M, Fairhead, M, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Godoy, A.S, Marples, P.G, Ni, X, Tomlinson, C.W.E, Wild, C, Fearon, D, Walsh, M.A, von Delft, F. | 登録日 | 2023-02-24 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structure of EV D68 3C protease To Be Published
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8CNY
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![BU of 8cny by Molmil](/molmil-images/mine/8cny) | Structure of Enterovirus A71 3C protease | 分子名称: | Protease 3C | 著者 | Lithgo, R.M, Fairhead, M, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Godoy, A.S, Marples, P.G, Ni, X, Tomlinson, C.W.E, Wild, C, Fearon, D, Walsh, M.A, von Delft, F. | 登録日 | 2023-02-24 | 公開日 | 2023-04-05 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Structure of EV D68 3C protease - to be published To Be Published
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7PP2
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![BU of 7pp2 by Molmil](/molmil-images/mine/7pp2) | Complex of rice blast (Magnaporthe oryzae) effector protein AVR-Pii with the host target Exo70F2 from Rice (Oryza sativa) | 分子名称: | AVR-Pii protein, Exocyst subunit Exo70 family protein, ZINC ION | 著者 | De la Concepcion, J.C, Bentham, A.R, Lawson, D, Banfield, M.J. | 登録日 | 2021-09-13 | 公開日 | 2022-06-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice. Proc.Natl.Acad.Sci.USA, 119, 2022
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7UT5
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![BU of 7ut5 by Molmil](/molmil-images/mine/7ut5) | Acinetobacter baumannii dihydroorotate dehydrogenase bound with inhibitor DSM186 | 分子名称: | (4R)-7-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ... | 著者 | Deng, X, Phillips, M, Tomchick, D. | 登録日 | 2022-04-26 | 公開日 | 2022-12-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. Proc.Natl.Acad.Sci.USA, 119, 2022
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7RPK
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![BU of 7rpk by Molmil](/molmil-images/mine/7rpk) | Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog | 分子名称: | (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | 登録日 | 2021-08-03 | 公開日 | 2021-10-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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7RPJ
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![BU of 7rpj by Molmil](/molmil-images/mine/7rpj) | Cryo-EM structure of murine Dispatched NNN mutant | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1 | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | 登録日 | 2021-08-03 | 公開日 | 2021-10-27 | 最終更新日 | 2021-11-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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7RPH
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![BU of 7rph by Molmil](/molmil-images/mine/7rph) | Cryo-EM structure of murine Dispatched 'R' conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | 登録日 | 2021-08-03 | 公開日 | 2021-10-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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7RPI
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![BU of 7rpi by Molmil](/molmil-images/mine/7rpi) | Cryo-EM structure of murine Dispatched 'T' conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, ... | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | 登録日 | 2021-08-03 | 公開日 | 2021-10-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog. Nature, 599, 2021
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7AL7
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![BU of 7al7 by Molmil](/molmil-images/mine/7al7) | The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18, Interleukin-18-binding protein | 著者 | Detry, S, Andries, J, Bloch, Y, Clancy, D, Savvides, S.N. | 登録日 | 2020-10-05 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. J.Biol.Chem., 298, 2022
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7P0W
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![BU of 7p0w by Molmil](/molmil-images/mine/7p0w) | Crystal structure of a trapped Pab-AGOG/double-standed DNA covalent intermediate (DNA containing thymine opposite to lesion) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*AP*GP*AP*AP*AP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*(PED)P*TP*TP*TP*CP*T)-3'), ... | 著者 | Coste, F, Goffinont, S, Flament, D, Castaing, B. | 登録日 | 2021-06-30 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Res., 50, 2022
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7AMA
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![BU of 7ama by Molmil](/molmil-images/mine/7ama) | IL-17A in complex with small molecule modulators | 分子名称: | Interleukin-17A, ~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide | 著者 | Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M. | 登録日 | 2020-10-08 | 公開日 | 2022-04-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J.Med.Chem., 65, 2022
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7AMG
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![BU of 7amg by Molmil](/molmil-images/mine/7amg) | IL-17A in complex with small molecule modulators | 分子名称: | (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl)propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]butanoic acid, Interleukin-17A | 著者 | Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M. | 登録日 | 2020-10-08 | 公開日 | 2022-04-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J.Med.Chem., 65, 2022
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7P27
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![BU of 7p27 by Molmil](/molmil-images/mine/7p27) | NMR solution structure of Chikungunya virus macro domain | 分子名称: | Polyprotein P1234 | 著者 | Lykouras, M.V, Tsika, A.C, Papageorgiou, N, Canard, B, Coutard, B, Bentrop, D, Spyroulias, G.A. | 登録日 | 2021-07-04 | 公開日 | 2022-07-13 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity. J.Mol.Biol., 434, 2022
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8QLP
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![BU of 8qlp by Molmil](/molmil-images/mine/8qlp) | CryoEM structure of the RNA/DNA bound SPARTA (BabAgo/TIR-APAZ) tetrameric complex | 分子名称: | DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*AP*TP*TP*AP*GP*AP*GP*CP*CP*GP*TP*C)-3'), MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... | 著者 | Finocchio, G, Koopal, B, Potocnik, A, Heijstek, C, Jinek, M, Swarts, D. | 登録日 | 2023-09-20 | 公開日 | 2024-01-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA. Nucleic Acids Res., 52, 2024
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8CO8
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![BU of 8co8 by Molmil](/molmil-images/mine/8co8) | Structure of West Nile Virus NS2B-NS3 protease | 分子名称: | Serine protease subunit NS2B,Serine protease/Helicase NS3 | 著者 | Fairhead, M, Godoy, A.S, Koekemoer, L, Balcomb, B.H, Lithgo, R.M, Aschenbrenner, J.C, Marples, P.G, Ni, X, Tomlinson, C.W.E, Wild, C, Fearon, D, Walsh, M.A, von Delft, F. | 登録日 | 2023-02-27 | 公開日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure of West Nile Virus NS2B-NS3 protease - to be published To Be Published
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