8QLP

CryoEM structure of the RNA/DNA bound SPARTA (BabAgo/TIR-APAZ) tetrameric complex

Summary for 8QLP

• Entry DOI: 10.2210/pdb8qlp/pdb
• EMDB information: 18487
• Descriptor: Toll/interleukin-1 receptor domain-containing protein, Short prokaryotic Argonaute, RNA (5'-R(*AP*UP*GP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... (5 entities in total)
• Functional Keywords: prokaryotic argonaute, tir domain, rna binding protein, dna binding protein, immune system, oligomerization, nadase activity
• Biological source: Bacillales bacterium; More
• Total number of polymer chains: 16
• Total formula weight: 501259.23

Authors

Finocchio, G.,Koopal, B.,Potocnik, A.,Heijstek, C.,Jinek, M.,Swarts, D. (deposition date: 2023-09-20, release date: 2024-01-31, Last modification date: 2024-03-06)

• Primary citation: Finocchio, G.,Koopal, B.,Potocnik, A.,Heijstek, C.,Westphal, A.H.,Jinek, M.,Swarts, D.C.; Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA.; Nucleic Acids Res., 52:2012-2029, 2024; PubMed: 38224450; DOI: 10.1093/nar/gkad1248

Experimental method

ELECTRON MICROSCOPY (3.14 Å)