7AL7
The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein
Summary for 7AL7
| Entry DOI | 10.2210/pdb7al7/pdb |
| Descriptor | Interleukin-18-binding protein, Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
| Functional Keywords | cytokine, decoy receptor, antagonist, complex |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 65108.75 |
| Authors | Detry, S.,Andries, J.,Bloch, Y.,Clancy, D.,Savvides, S.N. (deposition date: 2020-10-05, release date: 2022-04-20, Last modification date: 2024-01-31) |
| Primary citation | Detry, S.,Andries, J.,Bloch, Y.,Gabay, C.,Clancy, D.M.,Savvides, S.N. Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. J.Biol.Chem., 298:101908-101908, 2022 Cited by PubMed: 35398099DOI: 10.1016/j.jbc.2022.101908 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.801 Å) |
Structure validation
Download full validation report
