7AL7
The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0042007 | molecular_function | interleukin-18 binding |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006955 | biological_process | immune response |
| B | 0016740 | molecular_function | transferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:7538846, ECO:0000305|PubMed:12596270 |
| Chain | Residue | Details |
| B | TYR-184 | |
| B | TRP-150 | |
| B | ASN-137 | |
| B | GLN-124 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| B | TYR-80 | |
| A | ASN147 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CASP1, CASP4 and CASP5 => ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240 |
| Chain | Residue | Details |
| B | ASP36 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240 |
| Chain | Residue | Details |
| B | ASP71 |
