7AL7

The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-18-binding protein	polymer	172	18749.8	1	UniProt (O95998) Pfam (PF22009)	Homo sapiens (Human)	IL-18BP,Tadekinig-alfa
2	B (B)	Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18	polymer	390	45695.3	1	UniProt (P08515) UniProt (Q14116) Pfam (PF00340)	Schistosoma japonicum (Blood fluke)	GST 26,Sj26 antigen,SjGST,IL-18,Iboctadekin,Interferon gamma-inducing factor,IFN-gamma-inducing factor,Interleukin-1 gamma,IL-1 gamma
3	C, D, E (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
4	F, G (A, B)	water	water		18.0	130	Chemie (HOH)

Sequence modifications

A: 63 - 194 (UniProt: O95998)

PDB	External Database	Details
Thr 61	-	expression tag
Gly 62	-	expression tag
Gly 195	-	expression tag
Thr 196	-	expression tag
Ser 197	-	expression tag
Asp 198	-	expression tag
Glu 199	-	expression tag
Val 200	-	expression tag
Asp 201	-	expression tag
Gly 202	-	expression tag
Gly 203	-	expression tag
Ser 204	-	expression tag
Gly 205	-	expression tag
Gly 206	-	expression tag
Ser 207	-	expression tag
Gly 208	-	expression tag
Leu 209	-	expression tag
Asn 210	-	expression tag
Asp 211	-	expression tag
Ile 212	-	expression tag
Phe 213	-	expression tag
Glu 214	-	expression tag
Ala 215	-	expression tag
Gln 216	-	expression tag
Lys 217	-	expression tag
Ile 218	-	expression tag
Glu 219	-	expression tag
Trp 220	-	expression tag
His 221	-	expression tag
Glu 222	-	expression tag
Gly 223	-	expression tag
Arg 224	-	expression tag
Thr 225	-	expression tag
Lys 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag

B: -189 - 27 (UniProt: P08515)

PDB	External Database	Details
Met -196	-	initiating methionine
His -195	-	expression tag
His -194	-	expression tag
His -193	-	expression tag
His -192	-	expression tag
His -191	-	expression tag
His -190	-	expression tag
Ser 28	-	linker
Asp 29	-	linker
Arg 30	-	linker
Glu 31	-	linker
Phe 32	-	linker
Asp 33	-	linker
Glu 34	-	linker
Val 35	-	linker

B: 36 - 193 (UniProt: Q14116)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64445.1
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	65108.8

*Water molecules are not included.