7AL7
The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Interleukin-18-binding protein | polymer | 172 | 18749.8 | 1 | UniProt (O95998) Pfam (PF22009) In PDB | Homo sapiens (Human) | IL-18BP,Tadekinig-alfa |
2 | B | Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18 | polymer | 390 | 45695.3 | 1 | UniProt (P08515) UniProt (Q14116) Pfam (PF02798) Pfam (PF14497) Pfam (PF00340) In PDB | Schistosoma japonicum (Blood fluke) | GST 26,Sj26 antigen,SjGST,IL-18,Iboctadekin,Interferon gamma-inducing factor,IFN-gamma-inducing factor,Interleukin-1 gamma,IL-1 gamma |
3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
4 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 63 - 194 (UniProt: O95998)
B: -189 - 27 (UniProt: P08515)
B: 36 - 193 (UniProt: Q14116)
PDB | External Database | Details |
---|---|---|
Thr 61 | - | expression tag |
Gly 62 | - | expression tag |
Gly 195 | - | expression tag |
Thr 196 | - | expression tag |
Ser 197 | - | expression tag |
Asp 198 | - | expression tag |
Glu 199 | - | expression tag |
Val 200 | - | expression tag |
Asp 201 | - | expression tag |
Gly 202 | - | expression tag |
Gly 203 | - | expression tag |
Ser 204 | - | expression tag |
Gly 205 | - | expression tag |
Gly 206 | - | expression tag |
Ser 207 | - | expression tag |
Gly 208 | - | expression tag |
Leu 209 | - | expression tag |
Asn 210 | - | expression tag |
Asp 211 | - | expression tag |
Ile 212 | - | expression tag |
Phe 213 | - | expression tag |
Glu 214 | - | expression tag |
Ala 215 | - | expression tag |
Gln 216 | - | expression tag |
Lys 217 | - | expression tag |
Ile 218 | - | expression tag |
Glu 219 | - | expression tag |
Trp 220 | - | expression tag |
His 221 | - | expression tag |
Glu 222 | - | expression tag |
Gly 223 | - | expression tag |
Arg 224 | - | expression tag |
Thr 225 | - | expression tag |
Lys 226 | - | expression tag |
His 227 | - | expression tag |
His 228 | - | expression tag |
His 229 | - | expression tag |
His 230 | - | expression tag |
His 231 | - | expression tag |
His 232 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -196 | - | initiating methionine |
His -195 | - | expression tag |
His -194 | - | expression tag |
His -193 | - | expression tag |
His -192 | - | expression tag |
His -191 | - | expression tag |
His -190 | - | expression tag |
Ser 28 | - | linker |
Asp 29 | - | linker |
Arg 30 | - | linker |
Glu 31 | - | linker |
Phe 32 | - | linker |
Asp 33 | - | linker |
Glu 34 | - | linker |
Val 35 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 64445.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 65108.8 |