7AMG

IL-17A in complex with small molecule modulators

Summary for 7AMG

Entry DOI	10.2210/pdb7amg/pdb
Related	7AMA
Descriptor	Interleukin-17A, (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl)propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]butanoic acid (3 entities in total)
Functional Keywords	interleukin il-17a inhibitor receptor, immune system
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	52289.99
Authors	Hakansson, M.,Kimbung, R.,Logan, D.,Walse, U.B.,de Groot, M.J.,Andrews, M.D.,Dack, K.N.,Lambert, M. (deposition date: 2020-10-08, release date: 2022-04-20, Last modification date: 2024-01-31)
Primary citation	Andrews, M.D.,Dack, K.N.,de Groot, M.J.,Lambert, M.,Sennbro, C.J.,Larsen, M.,Stahlhut, M. Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J.Med.Chem., 65:8828-8842, 2022 Cited by PubMed: 35767390 DOI: 10.1021/acs.jmedchem.2c00422 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.18 Å)

Structure validation