7AMG

IL-17A in complex with small molecule modulators

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Interleukin-17A	polymer	109	12657.3	4	UniProt (Q16552) Pfam (PF06083)	Homo sapiens (Human)	IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8
2	E, F (A, D)	(3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl)propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]butanoic acid	non-polymer		830.3	2	Chemie (RMQ)
3	G, H, I (A, B, C)	water	water		18.0	10	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	50629.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1660.6
All*	Total formula weight	52290.0

*Water molecules are not included.