8Z1E
 
 | A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM | Descriptor: | Uncharacterized protein UL78 | Authors: | Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W. | Deposit date: | 2024-04-11 | Release date: | 2024-05-15 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM. Cell Discov, 10, 2024
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6O36
 
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6WCJ
 
 | Asymmetric vertex of the clathrin minicoat cage | Descriptor: | Clathrin heavy chain 1, Clathrin light chain B | Authors: | Paraan, M, Mendez, J, Sharum, S, Kurtin, D, He, H, Stagg, S. | Deposit date: | 2020-03-30 | Release date: | 2020-08-19 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | The structures of natively assembled clathrin-coated vesicles. Sci Adv, 6, 2020
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2M23
 
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6NUB
 
 | Pyruvate Kinase M2 Mutant - S437Y in Complex with L-serine | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Srivastava, D, Nandi, S, Dey, M. | Deposit date: | 2019-01-31 | Release date: | 2019-08-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 58, 2019
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2LYP
 
 | NOE-based 3D structure of the monomer of CylR2 in equilibrium with predissociated homodimer at 266K (-7 Celsius degrees) | Descriptor: | CylR2 | Authors: | Jaremko, M, Jaremko, L, Kim, H, Cho, M, Schwieters, C.D, Giller, K, Becker, S, Zweckstetter, M. | Deposit date: | 2012-09-19 | Release date: | 2013-02-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Cold denaturation of a protein dimer monitored at atomic resolution. Nat.Chem.Biol., 9, 2013
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6NV9
 
 | BACE1 in complex with a macrocyclic inhibitor | Descriptor: | (3S)-3-hydroxy-N-(2-methylpropyl)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-L-norleucinamide, Beta-secretase 1, SULFATE ION | Authors: | Yen, Y.C, Ghosh, A.K, Mesecar, A.D. | Deposit date: | 2019-02-04 | Release date: | 2019-10-09 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors. Biochemistry, 58, 2019
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2MGW
 
 | Solution Structure of the UBA Domain of Human NBR1 | Descriptor: | Next to BRCA1 gene 1 protein | Authors: | Walinda, E, Morimoto, D, Sugase, K, Komatsu, M, Tochio, H, Shirakawa, M. | Deposit date: | 2013-11-09 | Release date: | 2014-04-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin. J.Biol.Chem., 289, 2014
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2M1X
 
 | TICAM-1 TIR domain structure | Descriptor: | TIR domain-containing adapter molecule 1 | Authors: | Enokizono, Y, Kumeta, H, Funami, K, Horiuchi, M, Sarmiento, J, Yamashita, K, Standley, D.M, Matsumoto, M, Seya, T, Inagaki, F. | Deposit date: | 2012-12-07 | Release date: | 2014-01-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. Proc.Natl.Acad.Sci.USA, 110, 2013
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2MHY
 
 | Structure determination of the salamander courtship pheromone Plethodontid Modulating Factor | Descriptor: | Plethodontid modulating factor | Authors: | Wilburn, D.B, Bowen, K.E, Doty, K.A, Arumugam, S, Lane, A.N, Feldhoff, P.W, Feldhoff, R.C. | Deposit date: | 2013-12-05 | Release date: | 2014-01-01 | Last modified: | 2024-11-27 | Method: | SOLUTION NMR | Cite: | Structural insights into the evolution of a sexy protein: novel topology and restricted backbone flexibility in a hypervariable pheromone from the red-legged salamander, Plethodon shermani. Plos One, 9, 2014
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6NW3
 
 | BACE1 in complex with a macrocyclic inhibitor | Descriptor: | Beta-secretase 1, N-(2-methylpropyl)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-L-norleucinamide, SULFATE ION | Authors: | Yen, Y.C, Ghosh, A.K, Mesecar, A.D. | Deposit date: | 2019-02-05 | Release date: | 2019-10-09 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.352 Å) | Cite: | Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors. Biochemistry, 58, 2019
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2M2R
 
 | Solution structure of MCh-2: A novel inhibitor cystine knot peptide from Momordica charantia | Descriptor: | Inhibitor cystine knot peptide MCh-2 | Authors: | He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N. | Deposit date: | 2013-01-01 | Release date: | 2013-11-06 | Last modified: | 2024-11-27 | Method: | SOLUTION NMR | Cite: | Novel Inhibitor Cystine Knot Peptides from Momordica charantia. Plos One, 8, 2013
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2LXX
 
 | Solution structure of cofilin like UNC-60B protein from Caenorhabditis elegans | Descriptor: | Actin-depolymerizing factor 2, isoform c | Authors: | Shukla, V, Yadav, R, Kabra, A, Jain, A, Kumar, D, Ono, S, Arora, A. | Deposit date: | 2012-09-04 | Release date: | 2013-10-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure and dynamics of UNC-60B from Caenorhabditis elegans To be Published
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9FPP
 
 | FGD2 (Rv0132c) from Mycobacterium tuberculosis with cofactor F420 crystallised with Anderson-Evans polyoxotungstate | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 6-tungstotellurate(VI), COENZYME F420, ... | Authors: | Aderemi, A, Snee, M, Levy, C, Leys, D. | Deposit date: | 2024-06-13 | Release date: | 2025-06-25 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | FGD2 (Rv0132c) from Mycobacterium tuberculosis with cofactor F420 crystallised with Anderson-Evans polyoxotungstate To Be Published
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5LB2
 
 | Apo-structure of humanised RadA-mutant humRadA2 | Descriptor: | DNA repair and recombination protein RadA | Authors: | Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | Deposit date: | 2016-06-15 | Release date: | 2016-10-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
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7SI4
 
 | CRYSTAL STRUCTURE OF EED WITH MRTX-2219 | Descriptor: | (4S)-8-{4-[(dimethylamino)methyl]-2-methylphenyl}-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, FORMIC ACID, Polycomb protein EED | Authors: | Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A. | Deposit date: | 2021-10-12 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | CRYSTAL STRUCTURE OF EED WITH MRTX-2219 TO BE PUBLISHED
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6NIV
 
 | Racemic Phenol-Soluble Modulin Alpha 3 Peptide | Descriptor: | Phenol-soluble modulin PSM-alpha-3 | Authors: | Yao, Z, Cary, B.P, Bingman, C.A, Wang, C, Kreitler, D.F, Satyshur, K.A, Forest, K.T, Gellman, S.H. | Deposit date: | 2018-12-31 | Release date: | 2019-05-15 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin alpha 3 Toxicity. J.Am.Chem.Soc., 141, 2019
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6NOU
 
 | An scFv derived from ixekizumab | Descriptor: | GLYCEROL, scFv derived from ixekizumab | Authors: | Durbin, J.D, Clawson, D.K, Lu, F, Tian, Y, Lu, J, Atwell, S. | Deposit date: | 2019-01-16 | Release date: | 2019-06-19 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (1.914 Å) | Cite: | Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease. Mabs, 11, 2019
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5KTF
 
 | Structure of the C-terminal transmembrane domain of scavenger receptor BI (SR-BI) | Descriptor: | Scavenger receptor class B member 1 | Authors: | Chadwick, A.C, Peterson, F.C, Volkman, B.F, Sahoo, D. | Deposit date: | 2016-07-11 | Release date: | 2017-03-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif. Structure, 25, 2017
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3CVA
 
 | Human Bcl-xL containing a Trp to Ala mutation at position 137 | Descriptor: | Apoptosis regulator Bcl-X | Authors: | Feng, Y, Zhang, L, Hu, T, Shen, X, Chen, K, Jiang, H, Liu, D. | Deposit date: | 2008-04-18 | Release date: | 2009-03-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein Arch.Biochem.Biophys., 484, 2009
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5KPE
 
 | Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR664 | Descriptor: | De novo Beta Sheet Design Protein OR664 | Authors: | Tang, Y, Liu, G, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2016-07-03 | Release date: | 2016-09-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Principles for designing proteins with cavities formed by curved beta sheets. Science, 355, 2017
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9FKB
 
 | Tail of emppty Haloferax tailed virus 1 | Descriptor: | Baseplate to tube adapter protein gp41, HK97 gp6-like/SPP1 gp15-like head-tail connector, MAGNESIUM ION, ... | Authors: | Zhang, D, Daum, B, Isupov, M.N, McLaren, M. | Deposit date: | 2024-06-03 | Release date: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | CryoEM structure of Haloferax tailed virus To Be Published
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7QCX
 
 | Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, apo form | Descriptor: | Tyrosine-protein phosphatase non-receptor type 13 | Authors: | Ashkinadze, D, Kadavath, H, Chi, C, Friedmann, M, Strotz, D, Kumari, P, Minges, M, Cadalbert, R, Koenigl, S, Guentert, P, Voegeli, B, Riek, R. | Deposit date: | 2021-11-25 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Atomic resolution protein allostery from the multi-state structure of a PDZ domain. Nat Commun, 13, 2022
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2M0E
 
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7QCY
 
 | Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, complexed with RA-GEF2 peptide | Descriptor: | Tyrosine-protein phosphatase non-receptor type 13 | Authors: | Ashkinadze, D, Kadavath, H, Chi, C, Friedmann, M, Strotz, D, Kumari, P, Minges, M, Cadalbert, R, Koenigl, S, Guentert, P, Voegeli, B, Riek, R. | Deposit date: | 2021-11-25 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Atomic resolution protein allostery from the multi-state structure of a PDZ domain. Nat Commun, 13, 2022
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