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PDB: 56484 results

8Z1E
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BU of 8z1e by Molmil
A homotrimeric GPCR architecture of the human cytomegalovirus (UL78) revealed by cryo-EM
Descriptor: Uncharacterized protein UL78
Authors:Chen, Y, Li, Y, Zhou, Q, Cong, Z, Lin, S, Yan, J, Chen, X, Yang, D, Ying, T, Wang, M.-W.
Deposit date:2024-04-11
Release date:2024-05-15
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM.
Cell Discov, 10, 2024
6O36
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BU of 6o36 by Molmil
Crystal structure of human KRAS P34R mutant in complex with GNP
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Bera, A.K, Westover, K.D.
Deposit date:2019-02-26
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
Birth Defects Res, 112, 2020
6WCJ
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BU of 6wcj by Molmil
Asymmetric vertex of the clathrin minicoat cage
Descriptor: Clathrin heavy chain 1, Clathrin light chain B
Authors:Paraan, M, Mendez, J, Sharum, S, Kurtin, D, He, H, Stagg, S.
Deposit date:2020-03-30
Release date:2020-08-19
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:The structures of natively assembled clathrin-coated vesicles.
Sci Adv, 6, 2020
2M23
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BU of 2m23 by Molmil
NMR solution structure of the d3'-hairpin of the group II intron Sc.ai5gamma including EBS1 bound to IBS1
Descriptor: RNA (29-MER), RNA_(5'-R(*CP*AP*GP*UP*GP*UP*C)-3')_
Authors:Kruschel, D, Skilandat, M, Sigel, R.K.O.
Deposit date:2012-12-12
Release date:2013-12-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:NMR structure of the 5' splice site in the group IIB intron Sc.ai5 gamma--conformational requirements for exon-intron recognition.
Rna, 20, 2014
6NUB
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BU of 6nub by Molmil
Pyruvate Kinase M2 Mutant - S437Y in Complex with L-serine
Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Srivastava, D, Nandi, S, Dey, M.
Deposit date:2019-01-31
Release date:2019-08-21
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
Biochemistry, 58, 2019
2LYP
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BU of 2lyp by Molmil
NOE-based 3D structure of the monomer of CylR2 in equilibrium with predissociated homodimer at 266K (-7 Celsius degrees)
Descriptor: CylR2
Authors:Jaremko, M, Jaremko, L, Kim, H, Cho, M, Schwieters, C.D, Giller, K, Becker, S, Zweckstetter, M.
Deposit date:2012-09-19
Release date:2013-02-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Cold denaturation of a protein dimer monitored at atomic resolution.
Nat.Chem.Biol., 9, 2013
6NV9
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BU of 6nv9 by Molmil
BACE1 in complex with a macrocyclic inhibitor
Descriptor: (3S)-3-hydroxy-N-(2-methylpropyl)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-L-norleucinamide, Beta-secretase 1, SULFATE ION
Authors:Yen, Y.C, Ghosh, A.K, Mesecar, A.D.
Deposit date:2019-02-04
Release date:2019-10-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors.
Biochemistry, 58, 2019
2MGW
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BU of 2mgw by Molmil
Solution Structure of the UBA Domain of Human NBR1
Descriptor: Next to BRCA1 gene 1 protein
Authors:Walinda, E, Morimoto, D, Sugase, K, Komatsu, M, Tochio, H, Shirakawa, M.
Deposit date:2013-11-09
Release date:2014-04-09
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin.
J.Biol.Chem., 289, 2014
2M1X
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BU of 2m1x by Molmil
TICAM-1 TIR domain structure
Descriptor: TIR domain-containing adapter molecule 1
Authors:Enokizono, Y, Kumeta, H, Funami, K, Horiuchi, M, Sarmiento, J, Yamashita, K, Standley, D.M, Matsumoto, M, Seya, T, Inagaki, F.
Deposit date:2012-12-07
Release date:2014-01-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Proc.Natl.Acad.Sci.USA, 110, 2013
2MHY
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BU of 2mhy by Molmil
Structure determination of the salamander courtship pheromone Plethodontid Modulating Factor
Descriptor: Plethodontid modulating factor
Authors:Wilburn, D.B, Bowen, K.E, Doty, K.A, Arumugam, S, Lane, A.N, Feldhoff, P.W, Feldhoff, R.C.
Deposit date:2013-12-05
Release date:2014-01-01
Last modified:2024-11-27
Method:SOLUTION NMR
Cite:Structural insights into the evolution of a sexy protein: novel topology and restricted backbone flexibility in a hypervariable pheromone from the red-legged salamander, Plethodon shermani.
Plos One, 9, 2014
6NW3
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BU of 6nw3 by Molmil
BACE1 in complex with a macrocyclic inhibitor
Descriptor: Beta-secretase 1, N-(2-methylpropyl)-N~2~-{[(4S)-17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl}-L-norleucinamide, SULFATE ION
Authors:Yen, Y.C, Ghosh, A.K, Mesecar, A.D.
Deposit date:2019-02-05
Release date:2019-10-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.352 Å)
Cite:Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors.
Biochemistry, 58, 2019
2M2R
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BU of 2m2r by Molmil
Solution structure of MCh-2: A novel inhibitor cystine knot peptide from Momordica charantia
Descriptor: Inhibitor cystine knot peptide MCh-2
Authors:He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N.
Deposit date:2013-01-01
Release date:2013-11-06
Last modified:2024-11-27
Method:SOLUTION NMR
Cite:Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2LXX
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BU of 2lxx by Molmil
Solution structure of cofilin like UNC-60B protein from Caenorhabditis elegans
Descriptor: Actin-depolymerizing factor 2, isoform c
Authors:Shukla, V, Yadav, R, Kabra, A, Jain, A, Kumar, D, Ono, S, Arora, A.
Deposit date:2012-09-04
Release date:2013-10-09
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure and dynamics of UNC-60B from Caenorhabditis elegans
To be Published
9FPP
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BU of 9fpp by Molmil
FGD2 (Rv0132c) from Mycobacterium tuberculosis with cofactor F420 crystallised with Anderson-Evans polyoxotungstate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 6-tungstotellurate(VI), COENZYME F420, ...
Authors:Aderemi, A, Snee, M, Levy, C, Leys, D.
Deposit date:2024-06-13
Release date:2025-06-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:FGD2 (Rv0132c) from Mycobacterium tuberculosis with cofactor F420 crystallised with Anderson-Evans polyoxotungstate
To Be Published
5LB2
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BU of 5lb2 by Molmil
Apo-structure of humanised RadA-mutant humRadA2
Descriptor: DNA repair and recombination protein RadA
Authors:Marsh, M, Fischer, G, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M.
Deposit date:2016-06-15
Release date:2016-10-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
J.Mol.Biol., 428, 2016
7SI4
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BU of 7si4 by Molmil
CRYSTAL STRUCTURE OF EED WITH MRTX-2219
Descriptor: (4S)-8-{4-[(dimethylamino)methyl]-2-methylphenyl}-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, FORMIC ACID, Polycomb protein EED
Authors:Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A.
Deposit date:2021-10-12
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:CRYSTAL STRUCTURE OF EED WITH MRTX-2219
TO BE PUBLISHED
6NIV
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BU of 6niv by Molmil
Racemic Phenol-Soluble Modulin Alpha 3 Peptide
Descriptor: Phenol-soluble modulin PSM-alpha-3
Authors:Yao, Z, Cary, B.P, Bingman, C.A, Wang, C, Kreitler, D.F, Satyshur, K.A, Forest, K.T, Gellman, S.H.
Deposit date:2018-12-31
Release date:2019-05-15
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin alpha 3 Toxicity.
J.Am.Chem.Soc., 141, 2019
6NOU
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BU of 6nou by Molmil
An scFv derived from ixekizumab
Descriptor: GLYCEROL, scFv derived from ixekizumab
Authors:Durbin, J.D, Clawson, D.K, Lu, F, Tian, Y, Lu, J, Atwell, S.
Deposit date:2019-01-16
Release date:2019-06-19
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.914 Å)
Cite:Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease.
Mabs, 11, 2019
5KTF
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BU of 5ktf by Molmil
Structure of the C-terminal transmembrane domain of scavenger receptor BI (SR-BI)
Descriptor: Scavenger receptor class B member 1
Authors:Chadwick, A.C, Peterson, F.C, Volkman, B.F, Sahoo, D.
Deposit date:2016-07-11
Release date:2017-03-08
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif.
Structure, 25, 2017
3CVA
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BU of 3cva by Molmil
Human Bcl-xL containing a Trp to Ala mutation at position 137
Descriptor: Apoptosis regulator Bcl-X
Authors:Feng, Y, Zhang, L, Hu, T, Shen, X, Chen, K, Jiang, H, Liu, D.
Deposit date:2008-04-18
Release date:2009-03-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein
Arch.Biochem.Biophys., 484, 2009
5KPE
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BU of 5kpe by Molmil
Solution NMR Structure of Denovo Beta Sheet Design Protein, Northeast Structural Genomics Consortium (NESG) Target OR664
Descriptor: De novo Beta Sheet Design Protein OR664
Authors:Tang, Y, Liu, G, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
Deposit date:2016-07-03
Release date:2016-09-21
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Principles for designing proteins with cavities formed by curved beta sheets.
Science, 355, 2017
9FKB
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BU of 9fkb by Molmil
Tail of emppty Haloferax tailed virus 1
Descriptor: Baseplate to tube adapter protein gp41, HK97 gp6-like/SPP1 gp15-like head-tail connector, MAGNESIUM ION, ...
Authors:Zhang, D, Daum, B, Isupov, M.N, McLaren, M.
Deposit date:2024-06-03
Release date:2025-06-18
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:CryoEM structure of Haloferax tailed virus
To Be Published
7QCX
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BU of 7qcx by Molmil
Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, apo form
Descriptor: Tyrosine-protein phosphatase non-receptor type 13
Authors:Ashkinadze, D, Kadavath, H, Chi, C, Friedmann, M, Strotz, D, Kumari, P, Minges, M, Cadalbert, R, Koenigl, S, Guentert, P, Voegeli, B, Riek, R.
Deposit date:2021-11-25
Release date:2022-09-07
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Atomic resolution protein allostery from the multi-state structure of a PDZ domain.
Nat Commun, 13, 2022
2M0E
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BU of 2m0e by Molmil
Solution Structure of Miz-1 zinc finger 6
Descriptor: ZINC ION, Zinc finger and BTB domain-containing protein 17
Authors:Bernard, D, Bedard, M, Bilodeau, J, Lavigne, P.
Deposit date:2012-10-24
Release date:2012-11-14
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:NMR Structure Note: Solution Structure of Miz-1 Zinc Fingers 5 to 7
To be Published
7QCY
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BU of 7qcy by Molmil
Two-state liquid NMR Structure of a PDZ2 Domain from hPTP1E, complexed with RA-GEF2 peptide
Descriptor: Tyrosine-protein phosphatase non-receptor type 13
Authors:Ashkinadze, D, Kadavath, H, Chi, C, Friedmann, M, Strotz, D, Kumari, P, Minges, M, Cadalbert, R, Koenigl, S, Guentert, P, Voegeli, B, Riek, R.
Deposit date:2021-11-25
Release date:2022-09-07
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Atomic resolution protein allostery from the multi-state structure of a PDZ domain.
Nat Commun, 13, 2022

238895

数据于2025-07-16公开中

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