3CVA
Human Bcl-xL containing a Trp to Ala mutation at position 137
Summary for 3CVA
Entry DOI | 10.2210/pdb3cva/pdb |
Descriptor | Apoptosis regulator Bcl-X (2 entities in total) |
Functional Keywords | apoptosis, alternative splicing, membrane, mitochondrion, nucleus, transmembrane |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 |
Total number of polymer chains | 1 |
Total formula weight | 24604.97 |
Authors | |
Primary citation | Feng, Y.,Zhang, L.,Hu, T.,Shen, X.,Ding, J.,Chen, K.,Jiang, H.,Liu, D. A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein Arch.Biochem.Biophys., 484:46-54, 2009 Cited by PubMed: 19161970DOI: 10.1016/j.abb.2009.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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