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3CVA

Human Bcl-xL containing a Trp to Ala mutation at position 137

Functional Information from GO Data
ChainGOidnamespacecontents
X0001836biological_processrelease of cytochrome c from mitochondria
X0005515molecular_functionprotein binding
X0005737cellular_componentcytoplasm
X0005739cellular_componentmitochondrion
X0005741cellular_componentmitochondrial outer membrane
X0005743cellular_componentmitochondrial inner membrane
X0005759cellular_componentmitochondrial matrix
X0005783cellular_componentendoplasmic reticulum
X0005813cellular_componentcentrosome
X0005829cellular_componentcytosol
X0006897biological_processendocytosis
X0006915biological_processapoptotic process
X0006950biological_processresponse to stress
X0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
X0008637biological_processapoptotic mitochondrial changes
X0015267molecular_functionchannel activity
X0016020cellular_componentmembrane
X0019901molecular_functionprotein kinase binding
X0030672cellular_componentsynaptic vesicle membrane
X0031410cellular_componentcytoplasmic vesicle
X0031965cellular_componentnuclear membrane
X0031966cellular_componentmitochondrial membrane
X0032465biological_processregulation of cytokinesis
X0034097biological_processresponse to cytokine
X0042802molecular_functionidentical protein binding
X0042981biological_processregulation of apoptotic process
X0043065biological_processpositive regulation of apoptotic process
X0043066biological_processnegative regulation of apoptotic process
X0046902biological_processregulation of mitochondrial membrane permeability
X0051434molecular_functionBH3 domain binding
X0051607biological_processdefense response to virus
X0051707biological_processresponse to other organism
X0051881biological_processregulation of mitochondrial membrane potential
X0055085biological_processtransmembrane transport
X0090201biological_processnegative regulation of release of cytochrome c from mitochondria
X0097136cellular_componentBcl-2 family protein complex
X0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
X1900118biological_processnegative regulation of execution phase of apoptosis
X1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
X1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
X1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
X1902531biological_processregulation of intracellular signal transduction
X1903077biological_processnegative regulation of protein localization to plasma membrane
X2001233biological_processregulation of apoptotic signaling pathway
X2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
X2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
XTRP181-VAL192

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
XVAL86-ARG100

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
XSER4-TRP24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsMotif: {"description":"BH4"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues14
DetailsMotif: {"description":"BH3"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues19
DetailsMotif: {"description":"BH1"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues15
DetailsMotif: {"description":"BH2"}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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