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3CVA

Human Bcl-xL containing a Trp to Ala mutation at position 137

Functional Information from GO Data
ChainGOidnamespacecontents
X0001541biological_processovarian follicle development
X0001701biological_processin utero embryonic development
X0001836biological_processrelease of cytochrome c from mitochondria
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005737cellular_componentcytoplasm
X0005739cellular_componentmitochondrion
X0005741cellular_componentmitochondrial outer membrane
X0005743cellular_componentmitochondrial inner membrane
X0005759cellular_componentmitochondrial matrix
X0005783cellular_componentendoplasmic reticulum
X0005813cellular_componentcentrosome
X0005829cellular_componentcytosol
X0005856cellular_componentcytoskeleton
X0006897biological_processendocytosis
X0006915biological_processapoptotic process
X0006950biological_processresponse to stress
X0007005biological_processmitochondrion organization
X0007281biological_processgerm cell development
X0007283biological_processspermatogenesis
X0008584biological_processmale gonad development
X0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
X0008637biological_processapoptotic mitochondrial changes
X0009314biological_processresponse to radiation
X0009566biological_processfertilization
X0009615biological_processresponse to virus
X0016020cellular_componentmembrane
X0019901molecular_functionprotein kinase binding
X0030672cellular_componentsynaptic vesicle membrane
X0031410cellular_componentcytoplasmic vesicle
X0031965cellular_componentnuclear membrane
X0031966cellular_componentmitochondrial membrane
X0032465biological_processregulation of cytokinesis
X0032946biological_processpositive regulation of mononuclear cell proliferation
X0034097biological_processresponse to cytokine
X0035234biological_processectopic germ cell programmed cell death
X0040008biological_processregulation of growth
X0042802molecular_functionidentical protein binding
X0042981biological_processregulation of apoptotic process
X0043066biological_processnegative regulation of apoptotic process
X0043524biological_processnegative regulation of neuron apoptotic process
X0044565biological_processdendritic cell proliferation
X0045202cellular_componentsynapse
X0046898biological_processresponse to cycloheximide
X0046902biological_processregulation of mitochondrial membrane permeability
X0050673biological_processepithelial cell proliferation
X0051093biological_processnegative regulation of developmental process
X0051400molecular_functionBH domain binding
X0051402biological_processneuron apoptotic process
X0051434molecular_functionBH3 domain binding
X0051607biological_processdefense response to virus
X0051881biological_processregulation of mitochondrial membrane potential
X0071230biological_processcellular response to amino acid stimulus
X0071312biological_processcellular response to alkaloid
X0071480biological_processcellular response to gamma radiation
X0071839biological_processapoptotic process in bone marrow cell
X0090201biological_processnegative regulation of release of cytochrome c from mitochondria
X0097048biological_processdendritic cell apoptotic process
X0097136cellular_componentBcl-2 family protein complex
X0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
X0097284biological_processhepatocyte apoptotic process
X1900118biological_processnegative regulation of execution phase of apoptosis
X1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
X1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
X1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
X1903077biological_processnegative regulation of protein localization to plasma membrane
X2000242biological_processnegative regulation of reproductive process
X2000669biological_processnegative regulation of dendritic cell apoptotic process
X2001233biological_processregulation of apoptotic signaling pathway
X2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
X2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS01258
Number of Residues12
DetailsBH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
ChainResidueDetails
XTRP181-VAL192

site_idPS01259
Number of Residues15
DetailsBH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
ChainResidueDetails
XVAL86-ARG100

site_idPS01260
Number of Residues21
DetailsBH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
ChainResidueDetails
XSER4-TRP24

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by caspase-1
ChainResidueDetails
XASP61

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391
ChainResidueDetails
XSER49

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720
ChainResidueDetails
XSER62

219140

PDB entries from 2024-05-01

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