5L6Z
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6QH7
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![BU of 6qh7 by Molmil](/molmil-images/mine/6qh7) | AP2 clathrin adaptor mu2T156-phosphorylated core with two cargo peptides in open+ conformation | Descriptor: | ADAPTOR-RELATED PROTEIN COMPLEX 2, MU 2 SUBUNIT, C-TERMINAL DOMAIN, ... | Authors: | Wrobel, A.G, Owen, D.J, McCoy, A.J, Evans, P.R. | Deposit date: | 2019-01-15 | Release date: | 2019-09-04 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation. Dev.Cell, 50, 2019
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4UXX
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![BU of 4uxx by Molmil](/molmil-images/mine/4uxx) | Structure of delta4-DgkA with AMPPCP in 9.9 MAG | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | Authors: | Li, D, Vogeley, L, Caffrey, M. | Deposit date: | 2014-08-27 | Release date: | 2015-09-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase. Nat.Commun., 6, 2015
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6E8L
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![BU of 6e8l by Molmil](/molmil-images/mine/6e8l) | Crystal Structure of Alkyl hydroperoxidase D (AhpD) from Streptococcus pneumoniae (Strain D39/ NCTC 7466) | Descriptor: | Alkyl hydroperoxide reductase AhpD | Authors: | Meng, Y, Davies, J, North, R, Coombes, D, Horne, C, Hampton, M, Dobson, R. | Deposit date: | 2018-07-30 | Release date: | 2019-08-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-function analyses of alkylhydroperoxidase D fromStreptococcus pneumoniaereveal an unusual three-cysteine active site architecture. J.Biol.Chem., 295, 2020
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6EGK
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![BU of 6egk by Molmil](/molmil-images/mine/6egk) | T181N Cucumene Synthase | Descriptor: | Cucumene Synthase | Authors: | Blank, P.N, Pemberton, T.A, Christianson, D.W. | Deposit date: | 2018-08-20 | Release date: | 2018-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene. Biochemistry, 57, 2018
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3GXE
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![BU of 3gxe by Molmil](/molmil-images/mine/3gxe) | Complex of a Low Affinity Collagen Site with the Fibronectin 8-9FnI Domain Pair | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Collagen alpha-1(I) chain, Fibronectin, ... | Authors: | Sladek, B, Campbell, I.D, Vakonakis, I. | Deposit date: | 2009-04-02 | Release date: | 2010-04-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of collagen type I interactions with human fibronectin reveals a cooperative binding mode J.Biol.Chem., 288, 2013
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8QWN
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![BU of 8qwn by Molmil](/molmil-images/mine/8qwn) | Structure of p53 cancer mutant Y220C (hexagonal crystal form) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Cellular tumor antigen p53, ... | Authors: | Balourdas, D.I, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | Deposit date: | 2023-10-19 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Cell Death Dis, 15, 2024
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4ZZY
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![BU of 4zzy by Molmil](/molmil-images/mine/4zzy) | Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor | Descriptor: | 2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide, POLY [ADP-RIBOSE] POLYMERASE 2 | Authors: | Casale, E, Fasolini, M, Papeo, G, Posteri, H, Borghi, D, Busel, A.A, Caprera, F, Ciomei, M, Cirla, A, Corti, E, DAnello, M, Fasolini, M, Felder, E.R, Forte, B, Galvani, A, Isacchi, A, Khvat, A, Krasavin, M.Y, Lupi, R, Orsini, P, Perego, R, Pesenti, E, Pezzetta, D, Rainoldi, S, RiccardiSirtori, F, Scolaro, A, Sola, F, Zuccotto, F, Donati, D, Montagnoli, A. | Deposit date: | 2015-04-15 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery of 2-[1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl]-6-Fluoro-3-Oxo-2,3-Dihydro-1H-Isoindole-4-Carboxamide (Nms-P118): A Potent, Orally Available and Highly Selective Parp- 1 Inhibitor for Cancer Therapy. J.Med.Chem., 58, 2015
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5KNJ
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![BU of 5knj by Molmil](/molmil-images/mine/5knj) | Pseudokinase Domain of MLKL bound to Compound 1. | Descriptor: | 1-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethyloxy)phenyl]urea, Mixed lineage kinase domain-like protein | Authors: | Marcotte, D.J. | Deposit date: | 2016-06-28 | Release date: | 2016-11-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis. Plos One, 11, 2016
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6U3T
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![BU of 6u3t by Molmil](/molmil-images/mine/6u3t) | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | Descriptor: | Alpha-hemolysin, SULFATE ION, fos-choline-14 | Authors: | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | Deposit date: | 2019-08-22 | Release date: | 2020-03-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence. J.Biol.Chem., 295, 2020
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6ECA
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![BU of 6eca by Molmil](/molmil-images/mine/6eca) | Lactobacillus rhamnosus Beta-glucuronidase | Descriptor: | Beta-glucuronidase, CHLORIDE ION, GLYCEROL | Authors: | Biernat, K.A, Pellock, S.J, Bhatt, A.P, Bivins, M.M, Walton, W.G, Tran, B.N.T, Wei, L, Snider, M.C, Cesmat, A.P, Tripathy, A, Erie, D.A, Redinbo, M.R.R. | Deposit date: | 2018-08-07 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.853 Å) | Cite: | Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep, 9, 2019
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6QFM
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![BU of 6qfm by Molmil](/molmil-images/mine/6qfm) | Structure of human Mcl-1 in complex with PUMA BH3 peptide | Descriptor: | Bcl-2-binding component 3, CHLORIDE ION, Induced myeloid leukemia cell differentiation protein Mcl-1, ... | Authors: | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | Deposit date: | 2019-01-10 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4, 2019
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6EDS
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![BU of 6eds by Molmil](/molmil-images/mine/6eds) | Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63 | Descriptor: | 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | Authors: | Tan, G.A, Seeliger, M.A, Maianti, J.P, Liu, D.R, Welsh, A.J. | Deposit date: | 2018-08-10 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.18071723 Å) | Cite: | Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat.Chem.Biol., 15, 2019
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6U66
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![BU of 6u66 by Molmil](/molmil-images/mine/6u66) | Structure of the trimeric globular domain of Adiponectin | Descriptor: | Adiponectin, CALCIUM ION, SODIUM ION | Authors: | Pascolutti, R, Kruse, A.C, Erlandson, S.C, Burri, D.J, Zheng, S. | Deposit date: | 2019-08-29 | Release date: | 2020-01-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (0.99 Å) | Cite: | Mapping and engineering the interaction between adiponectin and T-cadherin. J.Biol.Chem., 295, 2020
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8QWK
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![BU of 8qwk by Molmil](/molmil-images/mine/8qwk) | Structure of p53 cancer mutant Y126C | Descriptor: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION | Authors: | Markl, A.M, Balourdas, D.I, Kraemer, A, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) | Deposit date: | 2023-10-19 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Cell Death Dis, 15, 2024
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6WU3
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8GVC
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![BU of 8gvc by Molmil](/molmil-images/mine/8gvc) | The cryo-EM structure of hAE2 with bicarbonate | Descriptor: | Anion exchange protein 2, BICARBONATE ION | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-14 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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5L1W
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3H94
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![BU of 3h94 by Molmil](/molmil-images/mine/3h94) | Crystal structure of the membrane fusion protein CusB from Escherichia coli | Descriptor: | Cation efflux system protein cusB, SILVER ION | Authors: | Su, C.-C, Yang, F, Long, F, Reyon, D, Routh, M.D, Kuo, D.W, Mokhtari, A.K, Van Ornam, J.D, Rabe, K.L, Hoy, J.A, Lee, Y.J, Rajashankar, K.R, Yu, E.W. | Deposit date: | 2009-04-30 | Release date: | 2009-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.84 Å) | Cite: | Crystal structure of the membrane fusion protein CusB from Escherichia coli J.Mol.Biol., 393, 2009
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5KNE
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![BU of 5kne by Molmil](/molmil-images/mine/5kne) | CryoEM Reconstruction of Hsp104 Hexamer | Descriptor: | Heat shock protein 104, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Yokom, A.L, Gates, S.N, Jackrel, M.E, Mack, K.L, Su, M, Shorter, J, Southworth, D.R. | Deposit date: | 2016-06-28 | Release date: | 2016-07-27 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (5.64 Å) | Cite: | Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nat.Struct.Mol.Biol., 23, 2016
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8GVH
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![BU of 8gvh by Molmil](/molmil-images/mine/8gvh) | Human AE2 in acidic KNO3 | Descriptor: | Anion exchange protein 2, CHOLESTEROL HEMISUCCINATE | Authors: | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | Deposit date: | 2022-09-15 | Release date: | 2023-04-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8QX8
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![BU of 8qx8 by Molmil](/molmil-images/mine/8qx8) | Endosomal membrane tethering complex CORVET | Descriptor: | E3 ubiquitin-protein ligase PEP5, Vacuolar membrane protein PEP3, Vacuolar protein sorting-associated protein 16, ... | Authors: | Shvarev, D, Ungermann, C, Moeller, A. | Deposit date: | 2023-10-23 | Release date: | 2024-07-03 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structure of the endosomal CORVET tethering complex. Nat Commun, 15, 2024
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8GY0
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![BU of 8gy0 by Molmil](/molmil-images/mine/8gy0) | Agrocybe pediades linalool sunthase (Ap.LS) | Descriptor: | Terpene synthase | Authors: | Rehka, T, Sharma, D, Lin, F, Lim, C, Choong, Y.K, Chacko, J, Zhang, C. | Deposit date: | 2022-09-21 | Release date: | 2023-04-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.988 Å) | Cite: | Structural Understanding of Fungal Terpene Synthases for the Formation of Linear or Cyclic Terpene Products. Acs Catalysis, 13, 2023
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6UE0
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![BU of 6ue0 by Molmil](/molmil-images/mine/6ue0) | Crystal structure of dihydrodipicolinate synthase from Klebsiella pneumoniae bound to pyruvate | Descriptor: | 4-hydroxy-tetrahydrodipicolinate synthase, CHLORIDE ION, SULFATE ION | Authors: | Impey, R.E, Lee, M, Hawkins, D.A, Sutton, J.M, Panjikar, S, Perugini, M.A, Soares da Costa, T.P. | Deposit date: | 2019-09-20 | Release date: | 2020-02-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens. Febs Lett., 594, 2020
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7R5O
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![BU of 7r5o by Molmil](/molmil-images/mine/7r5o) | |