5KNJ

Pseudokinase Domain of MLKL bound to Compound 1.

Summary for 5KNJ

• Entry DOI: 10.2210/pdb5knj/pdb
• Related: 5KO1
• Descriptor: Mixed lineage kinase domain-like protein, 1-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethyloxy)phenyl]urea (3 entities in total)
• Functional Keywords: pseudokinase domain mlkl compound 1 gfe out type 2 inhibitor, membrane proteins-inhibitor complex, membrane proteins/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q8NB16
• Total number of polymer chains: 2
• Total formula weight: 65613.43

Authors

Marcotte, D.J. (deposition date: 2016-06-28, release date: 2016-11-16, Last modification date: 2023-09-27)

• Primary citation: Ma, B.,Marcotte, D.,Paramasivam, M.,Michelsen, K.,Wang, T.,Bertolotti-Ciarlet, A.,Jones, J.H.,Moree, B.,Butko, M.,Salafsky, J.,Sun, X.,McKee, T.,Silvian, L.F.; ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.; Plos One, 11:e0165983-e0165983, 2016; PubMed: 27832137; DOI: 10.1371/journal.pone.0165983

Experimental method

X-RAY DIFFRACTION (2.88 Å)