5KNJ
Pseudokinase Domain of MLKL bound to Compound 1.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mixed lineage kinase domain-like protein | polymer | 283 | 32233.2 | 2 | UniProt (Q8NB16) Pfam (PF07714) | Homo sapiens (Human) | hMLKL |
| 2 | C, D (A, B) | 1-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethyloxy)phenyl]urea | non-polymer | 573.5 | 2 | Chemie (6UX) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 109 | Chemie (HOH) |
Sequence modifications
A, B: 191 - 471 (UniProt: Q8NB16)
| PDB | External Database | Details |
|---|---|---|
| Gly 189 | - | expression tag |
| Ser 190 | - | expression tag |
| Ala 366 | Glu 366 | engineered mutation |
| Ala 367 | Lys 367 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64466.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1147.1 | |
| All* | Total formula weight | 65613.4 |
