5KO1

Pseudokinase Domain of MLKL bound to Compound 4.

Summary for 5KO1

• Entry DOI: 10.2210/pdb5ko1/pdb
• Related: 5KNJ
• Descriptor: Mixed lineage kinase domain-like protein, [(1~{R})-2-[(4-fluorophenyl)amino]-2-oxidanylidene-1-phenyl-ethyl] 3-azanylpyrazine-2-carboxylate (3 entities in total)
• Functional Keywords: pseudokinase domain mlkl type1 inhibitor, membrane proteins-inhibitor complex, membrane proteins/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q8NB16
• Total number of polymer chains: 1
• Total formula weight: 32599.51

Authors

Marcotte, D.J. (deposition date: 2016-06-29, release date: 2016-11-16, Last modification date: 2023-09-27)

• Primary citation: Ma, B.,Marcotte, D.,Paramasivam, M.,Michelsen, K.,Wang, T.,Bertolotti-Ciarlet, A.,Jones, J.H.,Moree, B.,Butko, M.,Salafsky, J.,Sun, X.,McKee, T.,Silvian, L.F.; ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.; Plos One, 11:e0165983-e0165983, 2016; PubMed: 27832137; DOI: 10.1371/journal.pone.0165983

Experimental method

X-RAY DIFFRACTION (2.16 Å)