5KO1
Pseudokinase Domain of MLKL bound to Compound 4.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mixed lineage kinase domain-like protein | polymer | 283 | 32233.2 | 1 | UniProt (Q8NB16) Pfam (PF07714) | Homo sapiens (Human) | hMLKL |
| 2 | B (A) | [(1~{R})-2-[(4-fluorophenyl)amino]-2-oxidanylidene-1-phenyl-ethyl] 3-azanylpyrazine-2-carboxylate | non-polymer | 366.3 | 1 | Chemie (6UY) | |||
| 3 | C (A) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 191 - 471 (UniProt: Q8NB16)
| PDB | External Database | Details |
|---|---|---|
| Gly 189 | - | expression tag |
| Ser 190 | - | expression tag |
| Ala 366 | Glu 366 | engineered mutation |
| Ala 367 | Lys 367 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32233.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 366.3 | |
| All* | Total formula weight | 32599.5 |
