8QWN

Structure of p53 cancer mutant Y220C (hexagonal crystal form)

Summary for 8QWN

Entry DOI	10.2210/pdb8qwn/pdb
Descriptor	Cellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	tumor suppressor, transcription factor, cancer mutation, protein stability, conformational mutant, dna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	24780.11
Authors	Balourdas, D.I.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-10-19, release date: 2024-06-19)
Primary citation	Balourdas, D.I.,Markl, A.M.,Kramer, A.,Settanni, G.,Joerger, A.C. Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators. Cell Death Dis, 15:408-408, 2024 Cited by PubMed: 38862470 DOI: 10.1038/s41419-024-06739-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.44 Å)

Structure validation