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8QWK

Structure of p53 cancer mutant Y126C

Summary for 8QWK
Entry DOI10.2210/pdb8qwk/pdb
DescriptorCellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstumor suppressor, transcription factor, cancer mutation, protein stability, conformational mutant, dna binding protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight24658.29
Authors
Primary citationBalourdas, D.I.,Markl, A.M.,Kramer, A.,Settanni, G.,Joerger, A.C.
Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators.
Cell Death Dis, 15:408-408, 2024
Cited by
PubMed: 38862470
DOI: 10.1038/s41419-024-06739-x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

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PDB entries from 2024-07-17

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