7QNA
| Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN7
| Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 | 分子名称: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QND
| Cryo-EM structure of human full-length extrasynaptic beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN9
| Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN6
| Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QNB
| Cryo-EM structure of human full-length beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN8
| Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QNC
| Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one, ... | 著者 | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | 登録日 | 2021-12-20 | 公開日 | 2022-04-13 | 最終更新日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7NFE
| Cryo-EM structure of NHEJ super-complex (monomer) | 分子名称: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-06 | 公開日 | 2021-08-18 | 最終更新日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (4.29 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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3V42
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3VNN
| Crystal Structure of a sub-domain of the nucleotidyltransferase (adenylation) domain of human DNA ligase IV | 分子名称: | DNA ligase 4 | 著者 | Ochi, T, Wu, Q, Chirgadze, D.Y, Grossmann, J.G, Bolanos-Garcia, V.M, Blundell, T.L. | 登録日 | 2012-01-17 | 公開日 | 2012-06-20 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | 主引用文献 | Structural insights into the role of domain flexibility in human DNA ligase IV Structure, 20, 2012
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7NFC
| Cryo-EM structure of NHEJ super-complex (dimer) | 分子名称: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-05 | 公開日 | 2021-08-18 | 最終更新日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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6ZHE
| Cryo-EM structure of DNA-PK dimer | 分子名称: | DNA (25-MER), DNA (26-MER), DNA (27-MER), ... | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-23 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (7.24 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6ZHA
| Cryo-EM structure of DNA-PK monomer | 分子名称: | DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-21 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6ZH2
| Cryo-EM structure of DNA-PKcs (State 1) | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-20 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6ZH8
| Cryo-EM structure of DNA-PKcs:DNA | 分子名称: | DNA (5'-D(P*AP*CP*TP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*T)-3'), DNA-dependent protein kinase catalytic subunit,DNA-PKcs | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-21 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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1GMO
| CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... | 著者 | Lietha, D, Chirgadze, D.Y, Mulloy, B, Blundell, T.L, Gherardi, E. | 登録日 | 2001-09-20 | 公開日 | 2001-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor Embo J., 20, 2001
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1GMN
| CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEPATOCYTE GROWTH FACTOR | 著者 | Lietha, D, Chirgadze, D.Y, Mulloy, B, Blundell, T.L, Gherardi, E. | 登録日 | 2001-09-19 | 公開日 | 2001-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor Embo J., 20, 2001
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7A5V
| CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W. | 登録日 | 2020-08-22 | 公開日 | 2020-11-18 | 最終更新日 | 2020-11-25 | 実験手法 | ELECTRON MICROSCOPY (1.7 Å) | 主引用文献 | Single-particle cryo-EM at atomic resolution. Nature, 587, 2020
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7AUA
| Cryo-EM structure of human exostosin-like 3 (EXTL3) in complex with UDP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, MANGANESE (II) ION, ... | 著者 | Wilson, L.F.L, Dendooven, T, Hardwick, S.W, Chirgadze, D.Y, Luisi, B.F, Logan, D.T, Mani, K, Dupree, P. | 登録日 | 2020-11-02 | 公開日 | 2022-05-18 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis. Nat Commun, 13, 2022
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7AU2
| Cryo-EM structure of human exostosin-like 3 (EXTL3) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Wilson, L.F.L, Dendooven, T, Hardwick, S.W, Chirgadze, D.Y, Luisi, B.F, Logan, D.T, Mani, K, Dupree, P. | 登録日 | 2020-11-02 | 公開日 | 2022-05-18 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis. Nat Commun, 13, 2022
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3MKP
| Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex with heparin | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Gherardi, E, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2010-04-15 | 公開日 | 2010-08-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration To be Published
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6ZFP
| Cryo-EM structure of DNA-PKcs (State 2) | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-17 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6ZH6
| Cryo-EM structure of DNA-PKcs:Ku80ct194 | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5 | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-21 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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6ZH4
| Cryo-EM structure of DNA-PKcs (State 3) | 分子名称: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-20 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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