7A5V

CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc

Summary for 7A5V

• Entry DOI: 10.2210/pdb7a5v/pdb
• Related: 4COF
• EMDB information: 11657
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, CHLORIDE ION, Megabody Mb25, ... (11 entities in total)
• Functional Keywords: pentameric ligand-gated ion channel, neurotrasmitter receptor, gaba(a) receptor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 104693.20

Authors

Nakane, T.,Kotecha, A.,Sente, A.,Yamashita, K.,McMullan, G.,Masiulis, S.,Brown, P.M.G.E.,Grigoras, I.T.,Malinauskaite, L.,Malinauskas, T.,Miehling, J.,Yu, L.,Karia, D.,Pechnikova, E.V.,de Jong, E.,Keizer, J.,Bischoff, M.,McCormack, J.,Tiemeijer, P.,Hardwick, S.W.,Chirgadze, D.Y.,Murshudov, G.,Aricescu, A.R.,Scheres, S.H.W. (deposition date: 2020-08-22, release date: 2020-11-18, Last modification date: 2020-11-25)

• Primary citation: Nakane, T.,Kotecha, A.,Sente, A.,McMullan, G.,Masiulis, S.,Brown, P.M.G.E.,Grigoras, I.T.,Malinauskaite, L.,Malinauskas, T.,Miehling, J.,Uchanski, T.,Yu, L.,Karia, D.,Pechnikova, E.V.,de Jong, E.,Keizer, J.,Bischoff, M.,McCormack, J.,Tiemeijer, P.,Hardwick, S.W.,Chirgadze, D.Y.,Murshudov, G.,Aricescu, A.R.,Scheres, S.H.W.; Single-particle cryo-EM at atomic resolution.; Nature, 587:152-156, 2020; PubMed: 33087931; DOI: 10.1038/s41586-020-2829-0

Experimental method

ELECTRON MICROSCOPY (1.7 Å)