3MKP

Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex with heparin

Summary for 3MKP

• Entry DOI: 10.2210/pdb3mkp/pdb
• Related: 1BHT 1GMN 1GMO 1GP9 1NK1
• Descriptor: Hepatocyte growth factor, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, SULFATE ION, ... (6 entities in total)
• Functional Keywords: growth factor, supramolecular assembly, hgf/sf, met receptor, nk1, hormone
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 87891.49

Authors

Gherardi, E.,Chirgadze, D.Y.,Blundell, T.L. (deposition date: 2010-04-15, release date: 2010-08-18, Last modification date: 2023-11-01)

• Primary citation: Gherardi, E.,Chirgadze, D.Y.,Bocci, M.,Brocchieri, C.,Bevan, D.,Kajstura, J.,Esposito, G.,Lietha, D.,Rota, M.,Leri, A.,Mallorqui-Fernandez, N.,Bandyopadhyay, A.,Youles, M.,Mulloy, B.,Rowe, A.,Alison, M.,Edwards, D.,Vannini, V.,Blundell, T.,Anversa, P.; Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration; To be Published,

Experimental method

X-RAY DIFFRACTION (2.81 Å)