1GMO
CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
Summary for 1GMO
Entry DOI | 10.2210/pdb1gmo/pdb |
Related | 1BHT 1GMN 1GP9 1NK1 1SHY 1SI5 2CED 2CEE 2CEG 2HGF |
Descriptor | HEPATOCYTE GROWTH FACTOR, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (9 entities in total) |
Functional Keywords | hormone, growth factor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 8 |
Total formula weight | 184296.00 |
Authors | Lietha, D.,Chirgadze, D.Y.,Mulloy, B.,Blundell, T.L.,Gherardi, E. (deposition date: 2001-09-20, release date: 2001-10-02, Last modification date: 2023-12-13) |
Primary citation | Lietha, D.,Chirgadze, D.Y.,Mulloy, B.,Blundell, T.L.,Gherardi, E. Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor Embo J., 20:5543-, 2001 Cited by PubMed: 11597998DOI: 10.1093/EMBOJ/20.20.5543 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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