3MKP
Crystal structure of 1K1 mutant of Hepatocyte Growth Factor/Scatter Factor fragment NK1 in complex with heparin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Hepatocyte growth factor | polymer | 183 | 21116.1 | 4 | UniProt (P14210) Pfam (PF00024) Pfam (PF00051) | Homo sapiens (human) | Scatter factor, SF, Hepatopoeitin-A, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain |
| 2 | E (E) | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | branched | 1750.4 | 1 | In PDB GlyTouCan (G30141AL) | |||
| 3 | F, I, K, M (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, J, L, N (A, B, C, D) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) | |||
| 5 | H (A) | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose | non-polymer | 339.3 | 1 | Chemie (SGN) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 28 - 210 (UniProt: P14210)
| PDB | External Database | Details |
|---|---|---|
| Glu 132 | Lys 132 | engineered mutation |
| Glu 134 | Arg 134 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 84464.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1750.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1676.8 | |
| All* | Total formula weight | 87891.5 |
