7QNA

Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25

Summary for 7QNA

Entry DOI	10.2210/pdb7qna/pdb
EMDB information	14072
Descriptor	Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit gamma-2, ... (8 entities in total)
Functional Keywords	pentameric ligand-gated ion channel, neurotransmitter receptor, gaba receptor, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	298707.67
Authors	Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. (deposition date: 2021-12-20, release date: 2022-04-13, Last modification date: 2023-11-15)
Primary citation	Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604:190-194, 2022 Cited by PubMed: 35355020 DOI: 10.1038/s41586-022-04517-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation