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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7QNA

Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Gamma-aminobutyric acid receptor subunit alpha-4polymer55461696.01UniProt (P48169)
Pfam (PF02931)
Pfam (PF02932)		Homo sapiens (human)GABA(A) receptor subunit alpha-4
2B, D, E
(B, D, E)		Gamma-aminobutyric acid receptor subunit beta-3polymer47354180.33UniProt (P28472)
Pfam (PF02931)
Pfam (PF02932)		Homo sapiens (human)GABA(A) receptor subunit beta-3
3C
(C)		Gamma-aminobutyric acid receptor subunit gamma-2polymer48755666.81UniProt (A0A1W2PQX1)
Pfam (PF02931)
Pfam (PF02932)
UniProt (by SIFTS) (P18507)		Homo sapiens (human)
4F
(N)		Nanobody Nb25polymer12113341.71Lama glama
5G, I, K, M
(a, F, G, H)		alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched910.84In PDB
GlyTouCan (G22768VO)
6H, J, L
(b, d, e)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.43In PDB
GlyTouCan (G42666HT)
7N, P
(A, C)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
8O
(B)		GAMMA-AMINO-BUTANOIC ACIDnon-polymer103.11Chemie (ABU)
Sequence modifications
C: -22 - 391 (UniProt: A0A1W2PQX1)
PDBExternal DatabaseDetails
Met -30-initiating methionine
Gly -29-expression tag
Ile -28-expression tag
Leu -27-expression tag
Pro -26-expression tag
Ser -25-expression tag
Pro -24-expression tag
Gly -23-expression tag
Met -22Val 1conflict
Pro -21Trp 2conflict
Ala -20Ile 3conflict
Ser -17-insertion
Leu -16-insertion
Val -15-insertion
Ser -14-insertion
Val -10-insertion
Leu -8Tyr 10conflict
Met -7Pro 11conflict
Cys -5-insertion
Val -4-insertion
Ala -3-insertion
Glu -2Phe 13conflict
Gly 0Ser 15conflict
Thr 11Ala 26conflict
Leu 338-insertion
Leu 339-insertion
Arg 340-insertion
Met 341-insertion
Phe 342-insertion
Ser 343Lys 353conflict
Phe 344Val 354conflict
Lys 345Val 355conflict
Ala 346Leu 356conflict
Pro 347Leu 357conflict
Thr 348Arg 358conflict
Ile 349Val 359conflict
Asp 350Gly 360conflict
Arg 352Leu 362conflict
Arg 354Ala 364conflict
Ala 356Tyr 366conflict
Thr 357Asn 367conflict
Ile 358Lys 368conflict
Gln 359Asp 369conflict
Asn 361-insertion
Asn 362Arg 371conflict
Ala 363Thr 372conflict
Thr 364Gly 373conflict
His 365Phe 374conflict
Leu 366Gln 375conflict
Gln 367Thr 376conflict
Glu 368Ser 377conflict
Arg 369Ser 378conflict
Glu 372Ser 381conflict
Tyr 373Phe 382conflict
Tyr 375Lys 384conflict
Glu 376Ser 385conflict
Cys 377Pro 386conflict
Asp 379-insertion
Gly 380-insertion
Lys 381Ala 388conflict
Asp 382Leu 389conflict
Cys 383Ser 390conflict
Ala 384Val 391conflict
Phe 386-insertion
Phe 387Tyr 393conflict
Cys 388Ala 394conflict
Cys 389Ile 395conflict
Phe 390Ala 396conflict
Asp 392-expression tag
Cys 393-expression tag
Arg 394-expression tag
Thr 395-expression tag
Gly 396-expression tag
Ala 397-expression tag
Trp 398-expression tag
Arg 399-expression tag
His 400-expression tag
Gly 401-expression tag
Arg 402-expression tag
Ile 403-expression tag
His 404-expression tag
Ile 405-expression tag
Arg 406-expression tag
Ile 407-expression tag
Ala 408-expression tag
Lys 409-expression tag
Met 410-expression tag
Asp 411-expression tag
Ser 412-expression tag
Tyr 413-expression tag
Ala 414-expression tag
Arg 415-expression tag
Ile 416-expression tag
Phe 417-expression tag
Phe 418-expression tag
Pro 419-expression tag
Thr 420-expression tag
Ala 421-expression tag
Phe 422-expression tag
Cys 423-expression tag
Leu 424-expression tag
Phe 425-expression tag
Asn 426-expression tag
Leu 427-expression tag
Val 428-expression tag
Tyr 429-expression tag
Trp 430-expression tag
Val 431-expression tag
Ser 432-expression tag
Tyr 433-expression tag
Leu 434-expression tag
Tyr 435-expression tag
Leu 436-expression tag
Gly 437-expression tag
Thr 438-expression tag
Gly 439-expression tag
Gly 440-expression tag
Ser 441-expression tag
Gly 442-expression tag
Gly 443-expression tag
Ser 444-expression tag
Gly 445-expression tag
Gly 446-expression tag
Ser 447-expression tag
Thr 448-expression tag
Glu 449-expression tag
Thr 450-expression tag
Ser 451-expression tag
Gln 452-expression tag
Val 453-expression tag
Ala 454-expression tag
Pro 455-expression tag
Ala 456-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight293245.6
BranchedNumber of molecules7
Total formula weight4916.5
Non-Polymers*Number of molecules3
Total formula weight545.5
All*Total formula weight298707.7
*Water molecules are not included.

244693

PDB entries from 2025-11-12

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