7QNA
Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Gamma-aminobutyric acid receptor subunit alpha-4 | polymer | 554 | 61696.0 | 1 | UniProt (P48169) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit alpha-4 |
2 | B, D, E | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 473 | 54180.3 | 3 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit beta-3 |
3 | C | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 487 | 55666.8 | 1 | UniProt (A0A1W2PQX1) Pfam (PF02931) Pfam (PF02932) UniProt (by SIFTS) (P18507) In PDB | Homo sapiens (human) | |
4 | N | Nanobody Nb25 | polymer | 121 | 13341.7 | 1 | Lama glama | ||
5 | a, F, G, H | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
6 | b, d, e | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
7 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
8 | B | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 1 | Chemie (ABU) |
Sequence modifications
C: -22 - 391 (UniProt: A0A1W2PQX1)
PDB | External Database | Details |
---|---|---|
Met -30 | - | initiating methionine |
Gly -29 | - | expression tag |
Ile -28 | - | expression tag |
Leu -27 | - | expression tag |
Pro -26 | - | expression tag |
Ser -25 | - | expression tag |
Pro -24 | - | expression tag |
Gly -23 | - | expression tag |
Met -22 | Val 1 | conflict |
Pro -21 | Trp 2 | conflict |
Ala -20 | Ile 3 | conflict |
Ser -17 | - | insertion |
Leu -16 | - | insertion |
Val -15 | - | insertion |
Ser -14 | - | insertion |
Val -10 | - | insertion |
Leu -8 | Tyr 10 | conflict |
Met -7 | Pro 11 | conflict |
Cys -5 | - | insertion |
Val -4 | - | insertion |
Ala -3 | - | insertion |
Glu -2 | Phe 13 | conflict |
Gly 0 | Ser 15 | conflict |
Thr 11 | Ala 26 | conflict |
Leu 338 | - | insertion |
Leu 339 | - | insertion |
Arg 340 | - | insertion |
Met 341 | - | insertion |
Phe 342 | - | insertion |
Ser 343 | Lys 353 | conflict |
Phe 344 | Val 354 | conflict |
Lys 345 | Val 355 | conflict |
Ala 346 | Leu 356 | conflict |
Pro 347 | Leu 357 | conflict |
Thr 348 | Arg 358 | conflict |
Ile 349 | Val 359 | conflict |
Asp 350 | Gly 360 | conflict |
Arg 352 | Leu 362 | conflict |
Arg 354 | Ala 364 | conflict |
Ala 356 | Tyr 366 | conflict |
Thr 357 | Asn 367 | conflict |
Ile 358 | Lys 368 | conflict |
Gln 359 | Asp 369 | conflict |
Asn 361 | - | insertion |
Asn 362 | Arg 371 | conflict |
Ala 363 | Thr 372 | conflict |
Thr 364 | Gly 373 | conflict |
His 365 | Phe 374 | conflict |
Leu 366 | Gln 375 | conflict |
Gln 367 | Thr 376 | conflict |
Glu 368 | Ser 377 | conflict |
Arg 369 | Ser 378 | conflict |
Glu 372 | Ser 381 | conflict |
Tyr 373 | Phe 382 | conflict |
Tyr 375 | Lys 384 | conflict |
Glu 376 | Ser 385 | conflict |
Cys 377 | Pro 386 | conflict |
Asp 379 | - | insertion |
Gly 380 | - | insertion |
Lys 381 | Ala 388 | conflict |
Asp 382 | Leu 389 | conflict |
Cys 383 | Ser 390 | conflict |
Ala 384 | Val 391 | conflict |
Phe 386 | - | insertion |
Phe 387 | Tyr 393 | conflict |
Cys 388 | Ala 394 | conflict |
Cys 389 | Ile 395 | conflict |
Phe 390 | Ala 396 | conflict |
Asp 392 | - | expression tag |
Cys 393 | - | expression tag |
Arg 394 | - | expression tag |
Thr 395 | - | expression tag |
Gly 396 | - | expression tag |
Ala 397 | - | expression tag |
Trp 398 | - | expression tag |
Arg 399 | - | expression tag |
His 400 | - | expression tag |
Gly 401 | - | expression tag |
Arg 402 | - | expression tag |
Ile 403 | - | expression tag |
His 404 | - | expression tag |
Ile 405 | - | expression tag |
Arg 406 | - | expression tag |
Ile 407 | - | expression tag |
Ala 408 | - | expression tag |
Lys 409 | - | expression tag |
Met 410 | - | expression tag |
Asp 411 | - | expression tag |
Ser 412 | - | expression tag |
Tyr 413 | - | expression tag |
Ala 414 | - | expression tag |
Arg 415 | - | expression tag |
Ile 416 | - | expression tag |
Phe 417 | - | expression tag |
Phe 418 | - | expression tag |
Pro 419 | - | expression tag |
Thr 420 | - | expression tag |
Ala 421 | - | expression tag |
Phe 422 | - | expression tag |
Cys 423 | - | expression tag |
Leu 424 | - | expression tag |
Phe 425 | - | expression tag |
Asn 426 | - | expression tag |
Leu 427 | - | expression tag |
Val 428 | - | expression tag |
Tyr 429 | - | expression tag |
Trp 430 | - | expression tag |
Val 431 | - | expression tag |
Ser 432 | - | expression tag |
Tyr 433 | - | expression tag |
Leu 434 | - | expression tag |
Tyr 435 | - | expression tag |
Leu 436 | - | expression tag |
Gly 437 | - | expression tag |
Thr 438 | - | expression tag |
Gly 439 | - | expression tag |
Gly 440 | - | expression tag |
Ser 441 | - | expression tag |
Gly 442 | - | expression tag |
Gly 443 | - | expression tag |
Ser 444 | - | expression tag |
Gly 445 | - | expression tag |
Gly 446 | - | expression tag |
Ser 447 | - | expression tag |
Thr 448 | - | expression tag |
Glu 449 | - | expression tag |
Thr 450 | - | expression tag |
Ser 451 | - | expression tag |
Gln 452 | - | expression tag |
Val 453 | - | expression tag |
Ala 454 | - | expression tag |
Pro 455 | - | expression tag |
Ala 456 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 293245.6 | |
Branched | Number of molecules | 7 |
Total formula weight | 4916.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 545.5 | |
All* | Total formula weight | 298707.7 |