7QNA
Cryo-EM structure of human full-length alpha4beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0004890 | molecular_function | GABA-A receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0004890 | molecular_function | GABA-A receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0004890 | molecular_function | GABA-A receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006821 | biological_process | chloride transport |
| C | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0004890 | molecular_function | GABA-A receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0004890 | molecular_function | GABA-A receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CqLqLhnFPmDehsC |
| Chain | Residue | Details |
| C | CYS151-CYS165 | |
| A | CYS172-CYS186 | |
| B | CYS136-CYS150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 246 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| C | GLN1-PHE236 | |
| C | ARG284-ALA295 | |
| D | GLN1-PHE221 | |
| D | LEU268-LYS279 | |
| E | GLN1-PHE221 | |
| E | LEU268-LYS279 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 63 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53 |
| Chain | Residue | Details |
| C | THR237-ILE257 | |
| E | SER247-HIS267 | |
| E | ALA280-ASN303 | |
| E | ILE423-TYR445 | |
| C | ALA264-ALA283 | |
| C | MET296-PHE320 | |
| B | ILE423-TYR445 | |
| D | ILE222-ILE242 | |
| D | SER247-HIS267 | |
| D | ALA280-ASN303 | |
| D | ILE423-TYR445 | |
| E | ILE222-ILE242 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| C | ASN258-PRO263 | |
| B | TYR304-ALA422 | |
| D | ASN243-ALA246 | |
| D | TYR304-ALA422 | |
| E | ASN243-ALA246 | |
| E | TYR304-ALA422 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN13 | |
| C | ASN90 | |
| E | TYR446-ASN448 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6I53 |
| Chain | Residue | Details |
| C | ASN208 | |
| B | PHE200 | |
| D | ASP95 | |
| D | PHE200 | |
| E | ASP95 | |
| E | PHE200 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | TYR97 | |
| B | SER156 | |
| B | THR202 | |
| D | TYR97 | |
| D | SER156 | |
| D | THR202 | |
| E | TYR97 | |
| E | SER156 | |
| E | THR202 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | GLU155 | |
| D | GLU155 | |
| E | GLU155 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96 |
| Chain | Residue | Details |
| B | TYR157 | |
| D | TYR157 | |
| E | TYR157 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN8 | |
| D | ASN8 | |
| E | ASN8 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN80 | |
| D | ASN80 | |
| E | ASN80 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN149 | |
| D | ASN149 | |
| E | ASN149 |
