7AU2

Cryo-EM structure of human exostosin-like 3 (EXTL3)

Summary for 7AU2

Entry DOI	10.2210/pdb7au2/pdb
EMDB information	11923
Descriptor	Exostosin-like 3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	glycosyltransferase, heparan, n-acetylglucosaminyltransferase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	205756.40
Authors	Wilson, L.F.L.,Dendooven, T.,Hardwick, S.W.,Chirgadze, D.Y.,Luisi, B.F.,Logan, D.T.,Mani, K.,Dupree, P. (deposition date: 2020-11-02, release date: 2022-05-18, Last modification date: 2022-06-15)
Primary citation	Wilson, L.F.L.,Dendooven, T.,Hardwick, S.W.,Echevarria-Poza, A.,Tryfona, T.,Krogh, K.B.R.M.,Chirgadze, D.Y.,Luisi, B.F.,Logan, D.T.,Mani, K.,Dupree, P. The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis. Nat Commun, 13:3314-3314, 2022 Cited by PubMed: 35676258 DOI: 10.1038/s41467-022-31048-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.43 Å)

Structure validation