4FWF
| Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... | 著者 | Zhang, Q, Chen, Z. | 登録日 | 2012-07-01 | 公開日 | 2013-01-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
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7MIS
| Cryo-EM structure of SidJ-SdeC-CaM reaction intermediate complex | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | 著者 | Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S. | 登録日 | 2021-04-17 | 公開日 | 2021-08-18 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural and mechanistic basis for protein glutamylation by the kinase fold. Mol.Cell, 81, 2021
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7MIR
| Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | 著者 | Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S. | 登録日 | 2021-04-17 | 公開日 | 2021-08-18 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural and mechanistic basis for protein glutamylation by the kinase fold. Mol.Cell, 81, 2021
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4JDL
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7NNS
| Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound Momelotinib | 分子名称: | 1,2-ETHANEDIOL, Activin receptor type I, Momelotinib, ... | 著者 | Williams, E, Chen, Z, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | 登録日 | 2021-02-25 | 公開日 | 2021-04-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound Momelotinib To Be Published
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4JDA
| Complex structure of abscisic acid receptor PYL3 with (-)-ABA | 分子名称: | (2Z,4E)-5-[(1R)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3 | 著者 | Zhang, X, Wang, G, Chen, Z. | 登録日 | 2013-02-24 | 公開日 | 2013-07-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural Insights into the Abscisic Acid Stereospecificity by the ABA Receptors PYR/PYL/RCAR Plos One, 8, 2013
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5EDK
| Crystal structure of prothrombin deletion mutant residues 146-167 ( Form II ). | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... | 著者 | Pozzi, N, Chen, Z, Di Cera, E. | 登録日 | 2015-10-21 | 公開日 | 2016-01-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.214 Å) | 主引用文献 | How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin. J.Biol.Chem., 291, 2016
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4N0N
| Crystal structure of Arterivirus nonstructural protein 10 (helicase) | 分子名称: | MAGNESIUM ION, Replicase polyprotein 1ab, SULFATE ION, ... | 著者 | Deng, Z, Chen, Z. | 登録日 | 2013-10-02 | 公開日 | 2014-01-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res., 42, 2014
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4N0O
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4ZVV
| Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140 | 分子名称: | (2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Li, Y, Chen, Z, Eigenbrot, C. | 登録日 | 2015-05-18 | 公開日 | 2016-05-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat.Chem.Biol., 12, 2016
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4HZH
| Structure of recombinant Gla-domainless prothrombin mutant S525A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin | 著者 | Pozzi, N, Niu, W, Gohara, D.W, Chen, Z, Di Cera, E. | 登録日 | 2012-11-15 | 公開日 | 2013-06-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation. J.Biol.Chem., 288, 2013
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4O67
| Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.444 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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4O68
| Structure of human cyclic GMP-AMP synthase (cGAS) | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.436 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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4O69
| Human cyclic GMP-AMP synthase (cGAS) in complex with sulfate ion | 分子名称: | Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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4O6A
| Mouse cyclic GMP-AMP synthase (cGAS) in complex with DNA | 分子名称: | Cyclic GMP-AMP synthase, DNA1, DNA2, ... | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.859 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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5CI6
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8SNX
| Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the leader promoter | 分子名称: | Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*GP*CP*GP*U)-3'), RNA-directed RNA polymerase L | 著者 | Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. | 登録日 | 2023-04-28 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of the promoter-bound respiratory syncytial virus polymerase. Nature, 625, 2024
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8SNY
| Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the trailer complementary promoter | 分子名称: | Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*UP*CP*GP*U)-3'), RNA-directed RNA polymerase L | 著者 | Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. | 登録日 | 2023-04-28 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Structures of the promoter-bound respiratory syncytial virus polymerase. Nature, 625, 2024
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8STL
| Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha | 分子名称: | Nanobody PIK3_Nb16, SULFATE ION | 著者 | Nwafor, J.N, Srinivasan, L, Chen, Z, Gabelli, S.B, Iheanacho, A, Alzogaray, V, Klinke, S. | 登録日 | 2023-05-10 | 公開日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Development of isoform specific nanobodies for Class I PI3Ks To be published
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2OD3
| Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ... | 著者 | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | 登録日 | 2006-12-21 | 公開日 | 2007-04-10 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis of na+ activation mimicry in murine thrombin. J.Biol.Chem., 282, 2007
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2OCV
| Structural basis of Na+ activation mimicry in murine thrombin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin | 著者 | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | 登録日 | 2006-12-21 | 公開日 | 2007-04-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of na+ activation mimicry in murine thrombin. J.Biol.Chem., 282, 2007
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4H6S
| Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A | 分子名称: | Prothrombin, SODIUM ION | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | 登録日 | 2012-09-19 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Autoactivation of thrombin precursors. J.Biol.Chem., 288, 2013
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4H6T
| Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A | 分子名称: | PHOSPHATE ION, Prothrombin | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | 登録日 | 2012-09-19 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Autoactivation of thrombin precursors. J.Biol.Chem., 288, 2013
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3SQH
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3SQE
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