4ZVV
Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140
Summary for 4ZVV
Entry DOI | 10.2210/pdb4zvv/pdb |
Descriptor | L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | oxidoreductase inhibitor complex, ldha-g02792140, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P00338 |
Total number of polymer chains | 4 |
Total formula weight | 152261.01 |
Authors | Li, Y.,Chen, Z.,Eigenbrot, C. (deposition date: 2015-05-18, release date: 2016-05-18, Last modification date: 2023-09-27) |
Primary citation | Boudreau, A.,Purkey, H.E.,Hitz, A.,Robarge, K.,Peterson, D.,Labadie, S.,Kwong, M.,Hong, R.,Gao, M.,Del Nagro, C.,Pusapati, R.,Ma, S.,Salphati, L.,Pang, J.,Zhou, A.,Lai, T.,Li, Y.,Chen, Z.,Wei, B.,Yen, I.,Sideris, S.,McCleland, M.,Firestein, R.,Corson, L.,Vanderbilt, A.,Williams, S.,Daemen, A.,Belvin, M.,Eigenbrot, C.,Jackson, P.K.,Malek, S.,Hatzivassiliou, G.,Sampath, D.,Evangelista, M.,O'Brien, T. Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat.Chem.Biol., 12:779-786, 2016 Cited by PubMed: 27479743DOI: 10.1038/nchembio.2143 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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