Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4O68

Structure of human cyclic GMP-AMP synthase (cGAS)

Summary for 4O68
Entry DOI10.2210/pdb4o68/pdb
Related4O67 4O69 4O6A
DescriptorCyclic GMP-AMP synthase, ZINC ION (3 entities in total)
Functional Keywordsimmune responses, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytosol: Q8N884
Total number of polymer chains1
Total formula weight43916.03
Authors
Zhang, X.,Chen, Z.,Zhang, X.W.,Chen, Z.J. (deposition date: 2013-12-20, release date: 2014-02-05, Last modification date: 2024-02-28)
Primary citationZhang, X.,Wu, J.,Du, F.,Xu, H.,Sun, L.,Chen, Z.,Brautigam, C.A.,Zhang, X.,Chen, Z.J.
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.
Cell Rep, 6:421-430, 2014
Cited by
PubMed: 24462292
DOI: 10.1016/j.celrep.2014.01.003
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.436 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon