4O67

Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP

Summary for 4O67

• Entry DOI: 10.2210/pdb4o67/pdb
• Related: 4O68 4O69 4O6A
• Descriptor: Cyclic GMP-AMP synthase, cGAMP, ZINC ION, ... (4 entities in total)
• Functional Keywords: immune response, transferase
• Biological source: Homo sapiens
• Cellular location: Cytoplasm, cytosol : Q8N884
• Total number of polymer chains: 2
• Total formula weight: 86551.84

Authors

Zhang, X.,Chen, Z.,Zhang, X.W.,Chen, Z.J. (deposition date: 2013-12-20, release date: 2014-02-05, Last modification date: 2024-02-28)

• Primary citation: Zhang, X.,Wu, J.,Du, F.,Xu, H.,Sun, L.,Chen, Z.,Brautigam, C.A.,Zhang, X.,Chen, Z.J.; The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.; Cell Rep, 6:421-430, 2014; PubMed: 24462292; DOI: 10.1016/j.celrep.2014.01.003

Experimental method

X-RAY DIFFRACTION (2.444 Å)