7D9U
 
 | | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | | 分子名称: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | | 著者 | Chen, L, Liu, R, Kang, Y. | | 登録日 | 2020-10-14 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9S
 | | Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | 著者 | Chen, L, Liu, R, Kang, Y. | | 登録日 | 2020-10-14 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9T
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7DXC
 | | Structure of TRPC3 at 3.06 angstrom in low calcium state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
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7DXB
 | | Structure of TRPC3 at 2.7 angstrom in high calcium state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
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7DXD
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7DXG
 | | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
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7DXF
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7DXE
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7WIG
 | | Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | | 登録日 | 2022-01-03 | | 公開日 | 2022-06-01 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
Cell Res., 32, 2022
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7WIC
 | | Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | | 登録日 | 2022-01-03 | | 公開日 | 2022-06-01 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
Cell Res., 32, 2022
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7E16
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1DK4
 | | CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE | | 分子名称: | INOSITOL MONOPHOSPHATASE, PHOSPHATE ION, ZINC ION | | 著者 | Stec, B, Yang, H, Johnson, K.A, Chen, L, Roberts, M.F. | | 登録日 | 1999-12-06 | | 公開日 | 2000-11-08 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase.
Nat.Struct.Biol., 7, 2000
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4WK8
 | | FOXP3 forms a domain-swapped dimer to bridge DNA | | 分子名称: | DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), Forkhead box protein P3 | | 著者 | Chen, Y, Chen, L. | | 登録日 | 2014-10-01 | | 公開日 | 2015-01-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.4006 Å) | | 主引用文献 | DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res., 43, 2015
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5JKG
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4U5J
 | | C-Src in complex with Ruxolitinib | | 分子名称: | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Chen, Y, Duan, Y, Chen, L. | | 登録日 | 2014-07-25 | | 公開日 | 2014-09-17 | | 最終更新日 | 2022-03-23 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | c-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation
Plos One, 9, 2014
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4WBX
 | | Conserved hypothetical protein PF1771 from Pyrococcus furiosus solved by sulfur SAD using Swiss Light Source data | | 分子名称: | 2-keto acid:ferredoxin oxidoreductase subunit alpha | | 著者 | Weinert, T, Waltersperger, S, Olieric, V, Panepucci, E, Chen, L, Rose, J.P, Wang, M, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2014-09-04 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
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294D
 | | INTERCALATED CYTOSINE MOTIF AND NOVEL ADENINE CLUSTERS IN THE CRYSTAL STRUCTURE OF TETRAHYMENA TELOMERE | | 分子名称: | DNA (5'-D(*AP*AP*CP*CP*CP*C)-3') | | 著者 | Cai, L, Chen, L, Raghavan, S, Ratliff, R, Moyzis, R, Rich, A. | | 登録日 | 1996-10-30 | | 公開日 | 1998-10-19 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Intercalated cytosine motif and novel adenine clusters in the crystal structure of the Tetrahymena telomere.
Nucleic Acids Res., 26, 1998
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3B9L
 | | Human serum albumin complexed with myristate and AZT | | 分子名称: | 3'-azido-3'-deoxythymidine, MYRISTIC ACID, Serum albumin | | 著者 | Zhu, L, Yang, F, Chen, L, Meehan, E.J, Huang, M. | | 登録日 | 2007-11-05 | | 公開日 | 2008-05-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography
J.Struct.Biol., 162, 2008
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3B9M
 | | Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid | | 分子名称: | 2-HYDROXYBENZOIC ACID, 3'-azido-3'-deoxythymidine, MYRISTIC ACID, ... | | 著者 | Zhu, L, Yang, F, Chen, L, Meehan, E.J, Huang, M. | | 登録日 | 2007-11-05 | | 公開日 | 2008-05-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography
J.Struct.Biol., 162, 2008
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4ERG
 | | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase | | 分子名称: | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, FE (III) ION | | 著者 | Huo, L, Fielding, A.J, Chen, Y, Li, T, Iwaki, H, Hosler, J.P, Chen, L, Hasegawa, Y, Que Jr, L, Liu, A. | | 登録日 | 2012-04-20 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.789 Å) | | 主引用文献 | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
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4ERI
 | | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase | | 分子名称: | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, MAGNESIUM ION, ZINC ION | | 著者 | Huo, L, Fielding, A.J, Chen, Y, Li, T, Iwaki, H, Hosler, J.P, Chen, L, Hasegawa, Y, Que Jr, L, Liu, A. | | 登録日 | 2012-04-20 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.0006 Å) | | 主引用文献 | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
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4ERA
 | | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase | | 分子名称: | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, COBALT (II) ION | | 著者 | Huo, L, Fielding, A.J, Chen, Y, Li, T, Iwaki, H, Hosler, J.P, Chen, L, Hasegawa, Y, Que Jr, L, Liu, A. | | 登録日 | 2012-04-19 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | | 主引用文献 | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
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4EPK
 | | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase | | 分子名称: | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, MAGNESIUM ION, ZINC ION | | 著者 | Huo, L, Fielding, A.J, Chen, Y, Li, T, Iwaki, H, Hosler, J.P, Chen, L, Hasegawa, Y, Que Jr, L, Liu, A. | | 登録日 | 2012-04-17 | | 公開日 | 2012-08-22 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6009 Å) | | 主引用文献 | Evidence for a Dual Role of an Active Site Histidine in alpha-Amino-beta-Carboxymuconate-epsilon-Semialdehyde Decarboxylase
Biochemistry, 51, 2012
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1DCT
 | | DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA | | 分子名称: | CALCIUM ION, DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), ... | | 著者 | Reinisch, K.M, Chen, L, Verdine, G.L, Lipscomb, W.N. | | 登録日 | 1995-05-17 | | 公開日 | 1995-09-15 | | 最終更新日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing.
Cell(Cambridge,Mass.), 82, 1995
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