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PDB: 143 件
7ZOC
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BU of 7zoc by Molmil
Crystal structure of the peptidase domain of collagenase H from Clostridium histolyticum in complex with N-aryl-2-alkylmercaptoacetamide-based inhibitor
分子名称: CALCIUM ION, Collagenase ColH, ZINC ION, ...
著者Schoenauer, E, Brandstetter, H.
登録日2022-04-25
公開日2023-05-10
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH
Chemrxiv, 2022
5JBB
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BU of 5jbb by Molmil
Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with EGR-chloromethylketone
分子名称: CALCIUM ION, Coagulation factor IX, DIMETHYL SULFOXIDE, ...
著者Kristensen, L.H, Brandstetter, H.
登録日2016-04-13
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Biochem.J., 473, 2016
5JBC
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BU of 5jbc by Molmil
Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with PPACK
分子名称: CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
著者Kristensen, L.H, Brandstetter, H.
登録日2016-04-13
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Biochem.J., 473, 2016
8AE4
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BU of 8ae4 by Molmil
Crystal structure of human legumain in complex with Clitocypin 2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Clitocypin-2, ...
著者Elamin, T, Brandstetter, H, Dall, E.
登録日2022-07-12
公開日2022-09-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction.
J.Biol.Chem., 298, 2022
8AE5
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BU of 8ae5 by Molmil
Crystal structure of human legumain in complex with macrocypin 1a
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Legumain, ...
著者Elamin, T, Brandstetter, H, Dall, E.
登録日2022-07-12
公開日2022-09-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structural and functional studies of legumain-mycocypin complexes revealed a competitive, exosite-regulated mode of interaction.
J.Biol.Chem., 298, 2022
5JB9
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BU of 5jb9 by Molmil
Crystal structure of factor IXa K98T variant in complex with PPACK
分子名称: CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者Kristensen, L.H, Brandstetter, H.
登録日2016-04-13
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Biochem.J., 473, 2016
5JBA
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BU of 5jba by Molmil
Crystal structure of factor IXa variant V16I K98T Y177T I212V in complex with PPACK
分子名称: CALCIUM ION, Coagulation factor IX, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者Kristensen, L.H, Brandstetter, H.
登録日2016-04-13
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Biochem.J., 473, 2016
8B4V
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BU of 8b4v by Molmil
X-ray structure of furin (PCSK3) in complex with benzamidine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, CALCIUM ION, ...
著者Dahms, S.O, Brandstetter, H.
登録日2022-09-21
公開日2023-10-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Chemmedchem, 19, 2024
8B4W
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BU of 8b4w by Molmil
X-ray structure of furin (PCSK3) in complex with 1H-isoindol-3-amine
分子名称: 1H-isoindol-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Dahms, S.O, Brandstetter, H.
登録日2022-09-21
公開日2023-10-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Chemmedchem, 19, 2024
8B4X
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BU of 8b4x by Molmil
X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-R-Tle-K-6-(aminomethyl)-3-amino-isoindol
分子名称: CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Dahms, S.O, Brandstetter, H.
登録日2022-09-21
公開日2023-10-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Chemmedchem, 19, 2024
5JB8
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BU of 5jb8 by Molmil
Crystal structure of factor IXa variant K98T in complex with EGR-chloromethylketone
分子名称: CALCIUM ION, Coagulation factor IX, DIMETHYL SULFOXIDE, ...
著者Kristensen, L.H, Brandstetter, H.
登録日2016-04-13
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Releasing the brakes in coagulation Factor IXa by co-operative maturation of the substrate-binding site.
Biochem.J., 473, 2016
2WPM
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BU of 2wpm by Molmil
factor IXa superactive mutant, EGR-CMK inhibited
分子名称: CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ...
著者Zogg, T, Brandstetter, H.
登録日2009-08-06
公開日2009-12-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
2WPI
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BU of 2wpi by Molmil
factor IXa superactive double mutant
分子名称: CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ...
著者Zogg, T, Brandstetter, H.
登録日2009-08-06
公開日2009-12-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
2WPL
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factor IXa superactive triple mutant, EDTA-soaked
分子名称: COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, D-PHE-PRO-ARG-CHLOROMETHYL KETONE
著者Zogg, T, Brandstetter, H.
登録日2009-08-06
公開日2009-12-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
2WPJ
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factor IXa superactive triple mutant, NaCl-soaked
分子名称: CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ...
著者Zogg, T, Brandstetter, H.
登録日2009-08-06
公開日2009-12-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
2WPH
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BU of 2wph by Molmil
factor IXa superactive triple mutant
分子名称: CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, COAGULATION FACTOR IXA LIGHT CHAIN, ...
著者Zogg, T, Brandstetter, H.
登録日2009-08-06
公開日2009-12-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
2WPK
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BU of 2wpk by Molmil
factor IXa superactive triple mutant, ethylene glycol-soaked
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, COAGULATION FACTOR IXA HEAVY CHAIN, ...
著者Zogg, T, Brandstetter, H.
登録日2009-08-06
公開日2009-12-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structural Basis of the Cofactor- and Substrate-Assisted Activation of Human Coagulation Factor Ixa
Structure, 17, 2009
2Y50
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BU of 2y50 by Molmil
Crystal Structure of Collagenase G from Clostridium histolyticum at 2. 80 Angstrom Resolution
分子名称: CITRATE ANION, COLLAGENASE, HEXAETHYLENE GLYCOL, ...
著者Eckhard, U, Brandstetter, H.
登録日2011-01-11
公開日2011-09-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis
Nat.Struct.Mol.Biol., 18, 2011
2Y3U
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BU of 2y3u by Molmil
Crystal structure of apo collagenase G from Clostridium histolyticum at 2.55 Angstrom resolution
分子名称: CITRATE ANION, COLLAGENASE, DI(HYDROXYETHYL)ETHER, ...
著者Eckhard, U, Brandstetter, H.
登録日2010-12-26
公開日2011-09-28
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of Collagenase G Reveals a Chew-and -Digest Mechanism of Bacterial Collagenolysis
Nat.Struct.Mol.Biol., 18, 2011
5MS4
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BU of 5ms4 by Molmil
Kallikrein-related peptidase 8 leupeptin inhibitor complex
分子名称: CALCIUM ION, Kallikrein-8, LEUPEPTIN, ...
著者Debela, M, Magdolen, V, Skala, W, Bode, W, Brandstetter, H, Goettig, P.
登録日2016-12-30
公開日2018-01-17
最終更新日2019-10-09
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
Sci Rep, 8, 2018
5NIJ
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BU of 5nij by Molmil
Crystal structure of arabidopsis thaliana legumain isoform gamma in two-chain activation state
分子名称: CITRIC ACID, SULFATE ION, Vacuolar-processing enzyme gamma-isozyme
著者Zauner, F.B, Dall, E, Brandstetter, H.
登録日2017-03-24
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal Structure of Plant Legumain Reveals a Unique Two-Chain State with pH-Dependent Activity Regulation.
Plant Cell, 30, 2018
5MS3
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Kallikrein-related peptidase 8 calcium complex
分子名称: CALCIUM ION, Kallikrein-8
著者Debela, M, Magdolen, V, Skala, W, Bode, W, Brandstetter, H, Goettig, P.
登録日2016-12-30
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Specificity profiles and antagonistic Ca2+ and Zn2+ regulation of human KLK8/neuropsin activity by modules identified in crystal structures
To Be Published
5LPE
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BU of 5lpe by Molmil
Kallikrein-related peptidase 10 complex with Zn2+
分子名称: Kallikrein-10, SULFATE ION, ZINC ION
著者Goettig, P, Debela, M, Magdolen, V, Bode, W, Brandstetter, H.
登録日2016-08-12
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.
Biol.Chem., 397, 2016
5LPF
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Kallikrein-related peptidase 10
分子名称: Kallikrein-10, SULFATE ION
著者Goettig, P, Debela, M, Magdolen, V, Bode, W, Brandstetter, H.
登録日2016-08-12
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the Zn2+ inhibition of the zymogen-like kallikrein-related peptidase 10.
Biol.Chem., 397, 2016
1S0P
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BU of 1s0p by Molmil
Structure of the N-Terminal Domain of the Adenylyl Cyclase-Associated Protein (CAP) from Dictyostelium discoideum.
分子名称: Adenylyl cyclase-associated protein, MAGNESIUM ION
著者Ksiazek, D, Brandstetter, H, Israel, L, Bourenkov, G.P, Katchalova, G, Janssen, K.P, Bartunik, H.D, Noegel, A.A, Schleicher, M, Holak, T.A.
登録日2004-01-01
公開日2004-01-27
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献STRUCTURE OF THE N-TERMINAL DOMAIN OF THE ADENYLYL CYCLASE-ASSOCIATED PROTEIN (CAP) FROM DICTYOSTELIUM DISCOIDEUM
Structure, 11, 2003

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