233D
| THE CRYSTAL STRUCTURE ANALYSIS OF D(CGCGAASSCGCG)2: A SYNTHETIC DNA DODECAMER DUPLEX CONTAINING FOUR 4'-THIO-2'-DEOXYTHYMIDINE NUCLEOTIDES | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*)-D(*(T49)P*(T49)P*)-D(*CP*GP*CP*G)-3') | Authors: | Boggon, T.J, Hancox, E.L, McAuley-Hecht, K.E, Connolly, B.A, Hunter, W.N, Brown, T, Walker, R.T, Leonard, G.A. | Deposit date: | 1995-10-16 | Release date: | 1996-06-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides. Nucleic Acids Res., 24, 1996
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1YVJ
| Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue | Descriptor: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, Tyrosine-protein kinase JAK3 | Authors: | Boggon, T.J, Li, Y, Manley, P.W, Eck, M.J. | Deposit date: | 2005-02-15 | Release date: | 2005-05-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog Blood, 106, 2005
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1L3W
| C-cadherin Ectodomain | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Boggon, T.J, Murray, J, Chappuis-Flament, S, Wong, E, Gumbiner, B.M, Shapiro, L. | Deposit date: | 2002-03-01 | Release date: | 2002-04-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | C-cadherin ectodomain structure and implications for cell adhesion mechanisms Science, 296, 2002
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1C8Z
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8GI4
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8DGQ
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7LO0
| Structure of human ASF1a in complex with a TLK2 peptide | Descriptor: | Histone chaperone ASF1A, Serine/threonine-protein kinase tousled-like 2 | Authors: | Simon, B, Calderwood, D, Turk, B.E, Boggon, T.J. | Deposit date: | 2021-02-08 | Release date: | 2022-02-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Nat Commun, 13, 2022
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7LNY
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7TPB
| p120RasGAP SH3 domain in complex with DLC1 RhoGAP domain | Descriptor: | Ras GTPase-activating protein 1, Rho GTPase-activating protein 7 | Authors: | Stiegler, A.L, Boggon, T.J, Chau, J.E, Vish, K.J. | Deposit date: | 2022-01-25 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP. Nat Commun, 13, 2022
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4DX9
| ICAP1 in complex with integrin beta 1 cytoplasmic tail | Descriptor: | Integrin beta-1, Integrin beta-1-binding protein 1 | Authors: | Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J. | Deposit date: | 2012-02-27 | Release date: | 2013-01-09 | Last modified: | 2020-09-02 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation. Mol.Cell, 49, 2013
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3F6Q
| Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain | Descriptor: | IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ... | Authors: | Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | Deposit date: | 2008-11-06 | Release date: | 2008-12-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structural basis of integrin-linked kinase-PINCH interactions. Proc.Natl.Acad.Sci.USA, 105, 2008
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2KQ6
| The structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity | Descriptor: | Polycystin-2 | Authors: | Petri, E.T, Celic, A, Kennedy, S.D, Ehrlich, B.E, Boggon, T.J, Hodsdon, M.E. | Deposit date: | 2009-10-28 | Release date: | 2010-05-12 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Proc.Natl.Acad.Sci.USA, 107, 2010
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4Y5O
| CCM2 HHD in complex with MEKK3 NPB1 | Descriptor: | Malcavernin, Mitogen-activated protein kinase kinase kinase 3 | Authors: | Fisher, O.S, Boggon, T.J. | Deposit date: | 2015-02-11 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun, 6, 2015
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3IXE
| Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase | Descriptor: | Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION | Authors: | Chiswell, B.P, Stiegler, A.L, Boggon, T.J, Calderwood, D.A. | Deposit date: | 2009-09-03 | Release date: | 2009-12-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. J.Struct.Biol., 170, 2010
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5D68
| Crystal structure of KRIT1 ARD-FERM | Descriptor: | Krev interaction trapped protein 1 | Authors: | Zhang, R, Li, X, Boggon, T.J. | Deposit date: | 2015-08-11 | Release date: | 2015-10-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.908 Å) | Cite: | Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface. J.Struct.Biol., 192, 2015
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4PGZ
| Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit | Authors: | Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. | Deposit date: | 2014-05-03 | Release date: | 2015-03-18 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. Mol.Cell, 57, 2015
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4XLI
| Crystal structure of Abl2/Arg kinase in complex with dasatinib | Descriptor: | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Non-specific protein-tyrosine kinase, ZINC ION | Authors: | Ha, B.H, Boggon, T.J. | Deposit date: | 2015-01-13 | Release date: | 2015-04-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the ABL2/ARG kinase in complex with dasatinib. Acta Crystallogr.,Sect.F, 71, 2015
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1I7E
| C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate | Descriptor: | L-ALPHA-GLYCEROPHOSPHO-D-MYO-INOSITOL-4,5-BIS-PHOSPHATE, TUBBY PROTEIN | Authors: | Santagata, S, Boggon, T.J, Baird, C.L, Shan, W.S, Shapiro, L. | Deposit date: | 2001-03-08 | Release date: | 2001-06-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | G-protein signaling through tubby proteins. Science, 292, 2001
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4WJ7
| CCM2 PTB domain in complex with KRIT1 NPxY/F3 | Descriptor: | KRIT1 NPxY/F3, Malcavernin | Authors: | Fisher, O.S, Liu, W, Zhang, R, Stiegler, A.L, Boggon, T.J. | Deposit date: | 2014-09-29 | Release date: | 2014-12-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.753 Å) | Cite: | Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations. J.Biol.Chem., 290, 2015
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4TKN
| Structure of the SNX17 FERM domain bound to the second NPxF motif of KRIT1 | Descriptor: | Krev interaction trapped protein 1, Sorting nexin-17 | Authors: | Stiegler, A.L, Zhang, R, Liu, W, Boggon, T.J. | Deposit date: | 2014-05-27 | Release date: | 2014-07-30 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1). J.Biol.Chem., 289, 2014
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4TVQ
| CCM3 in complex with CCM2 LD-like motif | Descriptor: | Cerebral cavernous malformations 2 protein, Cerebral cavernous malformations 3 protein | Authors: | Li, X, Zhang, R, Fisher, O.S, Boggon, T.J. | Deposit date: | 2014-06-27 | Release date: | 2015-03-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. J.Cell Biol., 208, 2015
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6PXC
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6PXB
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5HVJ
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5HVK
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