9OFX

Crystal structure of c-Src SH3 domain in H32 space group mediated by nickel

Summary for 9OFX

Entry DOI	10.2210/pdb9ofx/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, NICKEL (II) ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	sh3 domain, nickel, src, atcun, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	27427.02
Authors	Stiegler, A.L.,Calicdan, X.,Ha, B.H.,Fisher, O.S.,Boggon, T.J. (deposition date: 2025-04-30, release date: 2025-05-14, Last modification date: 2025-10-22)
Primary citation	Calicdan, X.,Fisher, O.S.,Ha, B.H.,Boggon, T.J.,Stiegler, A.L. Nickel Binding to the c-Src SH3 Domain Facilitates Crystallization. Protein Pept.Lett., 2025 Cited by PubMed Abstract: Numerous X-ray crystal structures of the c-Src SH3 domain have provided a large sampling of atomic-level information for this important signaling domain. Multiple crystal forms have been reported, with variable crystal lattice contacts and chemical crystallization conditions. PubMed: 41088944 DOI: 10.2174/0109298665417324250929120040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation