4ZLP
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![BU of 4zlp by Molmil](/molmil-images/mine/4zlp) | Crystal Structure of Notch3 Negative Regulatory Region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2015-05-01 | Release date: | 2015-08-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.479 Å) | Cite: | Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure, 23, 2015
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5TCX
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![BU of 5tcx by Molmil](/molmil-images/mine/5tcx) | Crystal structure of human tetraspanin CD81 | Descriptor: | CD81 antigen, CHOLESTEROL | Authors: | Zimmerman, B, McMillan, B.J, Seegar, T.C.M, Kruse, A.C, Blacklow, S.C. | Deposit date: | 2016-09-16 | Release date: | 2016-11-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell, 167, 2016
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5UX6
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![BU of 5ux6 by Molmil](/molmil-images/mine/5ux6) | Structure of Human POFUT1 in its apo form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GDP-fucose protein O-fucosyltransferase 1, GLYCEROL | Authors: | Xu, X, McMillan, B, Blacklow, S.C. | Deposit date: | 2017-02-22 | Release date: | 2017-04-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology, 27, 2017
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5UXH
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![BU of 5uxh by Molmil](/molmil-images/mine/5uxh) | Structure of Human POFUT1 in complex with GDP-fucose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GDP-fucose protein O-fucosyltransferase 1, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE | Authors: | Xu, X, McMillan, B, Blacklow, S.C. | Deposit date: | 2017-02-22 | Release date: | 2017-04-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology, 27, 2017
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5VNY
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![BU of 5vny by Molmil](/molmil-images/mine/5vny) | |
5IGQ
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![BU of 5igq by Molmil](/molmil-images/mine/5igq) | |
5I6V
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![BU of 5i6v by Molmil](/molmil-images/mine/5i6v) | |
5J45
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![BU of 5j45 by Molmil](/molmil-images/mine/5j45) | |
1PB5
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![BU of 1pb5 by Molmil](/molmil-images/mine/1pb5) | NMR Structure of a Prototype LNR Module from Human Notch1 | Descriptor: | CALCIUM ION, Neurogenic locus notch homolog protein 1 | Authors: | Vardar, D, North, C.L, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. | Deposit date: | 2003-05-14 | Release date: | 2003-06-17 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1 Biochemistry, 42, 2003
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5L2Q
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![BU of 5l2q by Molmil](/molmil-images/mine/5l2q) | |
1NTV
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![BU of 1ntv by Molmil](/molmil-images/mine/1ntv) | Crystal Structure of the Disabled-1 (Dab1) PTB domain-ApoER2 peptide complex | Descriptor: | Apolipoprotein E Receptor-2 peptide, Disabled homolog 1, PHOSPHATE ION | Authors: | Stolt, P.C, Jeon, H, Song, H.K, Herz, J, Eck, M.J, Blacklow, S.C. | Deposit date: | 2003-01-30 | Release date: | 2003-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes Structure, 11, 2003
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1Q69
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![BU of 1q69 by Molmil](/molmil-images/mine/1q69) | Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments | Descriptor: | Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD8 alpha chain, ZINC ION | Authors: | Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J. | Deposit date: | 2003-08-12 | Release date: | 2003-11-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science, 301, 2003
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1Q68
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![BU of 1q68 by Molmil](/molmil-images/mine/1q68) | Solution structure of T-cell surface glycoprotein CD4 and Proto-oncogene tyrosine-protein kinase LCK fragments | Descriptor: | Proto-oncogene tyrosine-protein kinase LCK, T-cell surface glycoprotein CD4, ZINC ION | Authors: | Kim, P.W, Sun, Z.Y, Blacklow, S.C, Wagner, G, Eck, M.J. | Deposit date: | 2003-08-12 | Release date: | 2003-11-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science, 301, 2003
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1NU2
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![BU of 1nu2 by Molmil](/molmil-images/mine/1nu2) | Crystal structure of the murine Disabled-1 (Dab1) PTB domain-ApoER2 peptide-PI-4,5P2 ternary complex | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Disabled homolog 1, peptide derived from murine Apolipoprotein E Receptor-2 | Authors: | Stolt, P.C, Jeon, H, Song, H.K, Herz, J, Eck, M.J, Blacklow, S.C. | Deposit date: | 2003-01-30 | Release date: | 2003-04-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes Structure, 11, 2003
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4XI7
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![BU of 4xi7 by Molmil](/molmil-images/mine/4xi7) | |
4XIB
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![BU of 4xib by Molmil](/molmil-images/mine/4xib) | |
4XI6
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![BU of 4xi6 by Molmil](/molmil-images/mine/4xi6) | |
3NBN
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![BU of 3nbn by Molmil](/molmil-images/mine/3nbn) | |
3I08
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![BU of 3i08 by Molmil](/molmil-images/mine/3i08) | |
3ETO
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![BU of 3eto by Molmil](/molmil-images/mine/3eto) | |
2OO4
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![BU of 2oo4 by Molmil](/molmil-images/mine/2oo4) | Structure of LNR-HD (Negative Regulatory Region) from human Notch 2 | Descriptor: | CALCIUM ION, GLYCEROL, Neurogenic locus notch homolog protein 2, ... | Authors: | Gordon, W.R, Vardar-Ulu, D, Histen, G, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. | Deposit date: | 2007-01-25 | Release date: | 2007-04-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Structural basis for autoinhibition of Notch Nat.Struct.Mol.Biol., 14, 2007
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6CD5
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![BU of 6cd5 by Molmil](/molmil-images/mine/6cd5) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor XMD17-26 | Descriptor: | 1,2-ETHANEDIOL, 11-cyclopentyl-2-[[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl-phenyl]amino]-5-methyl-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4, ... | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2018-02-08 | Release date: | 2019-01-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13, 2018
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6CJ2
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![BU of 6cj2 by Molmil](/molmil-images/mine/6cj2) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG056 | Descriptor: | 2-{[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5-methyl-11-(propan-2-yl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4 | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2018-02-26 | Release date: | 2019-03-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. Acs Chem.Biol., 13, 2018
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6CJ1
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![BU of 6cj1 by Molmil](/molmil-images/mine/6cj1) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG071 | Descriptor: | 1,2-ETHANEDIOL, 11-[(2R)-butan-2-yl]-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, 11-[(2S)-butan-2-yl]-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, ... | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2018-02-25 | Release date: | 2018-08-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13, 2018
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6CIS
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![BU of 6cis by Molmil](/molmil-images/mine/6cis) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG047 | Descriptor: | 1,2-ETHANEDIOL, 11-cyclopentyl-5-methyl-2-({4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]-2-[(propan-2-yl)oxy]phenyl}amino)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4, ... | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2018-02-25 | Release date: | 2018-08-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem. Biol., 13, 2018
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