3NBN

Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA

Summary for 3NBN

Entry DOI	10.2210/pdb3nbn/pdb
Descriptor	Recombining binding protein suppressor of hairless, Neurogenic locus notch homolog protein 1, Mastermind-like protein 1, ... (5 entities in total)
Functional Keywords	promoter regions, notch1, csl, rbpj, mastermind, transcription factors, transcription, transcriptional activation, transcription-dna complex, transcription/dna
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: Q06330 Cell membrane ; Single-pass type I membrane protein . Notch 1 intracellular domain: Nucleus : P46531 Nucleus speckle : Q92585
Total number of polymer chains	8
Total formula weight	192047.56
Authors	Arnett, K.L.,Blacklow, S.C. (deposition date: 2010-06-03, release date: 2010-11-03, Last modification date: 2023-09-06)
Primary citation	Arnett, K.L.,Hass, M.,McArthur, D.G.,Ilagan, M.X.,Aster, J.C.,Kopan, R.,Blacklow, S.C. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat.Struct.Mol.Biol., 17:1312-1317, 2010 Cited by PubMed: 20972443 DOI: 10.1038/nsmb.1938 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.45 Å)

Structure validation