3NBN

Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Recombining binding protein suppressor of hairless	polymer	433	49237.2	2	UniProt (Q06330) Pfam (PF09271) Pfam (PF09270) Pfam (PF20144) In PDB	Homo sapiens (human)	J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, RBP-J, CBF-1, Renal carcinoma antigen NY-REN-30
2	B, E	Neurogenic locus notch homolog protein 1	polymer	256	27885.0	2	UniProt (P46531) Pfam (PF00023) Pfam (PF12796) In PDB	Homo sapiens (human)	Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, Notch 1 intracellular domain
3	C, F	Mastermind-like protein 1	polymer	63	7532.8	2	UniProt (Q92585) Pfam (PF09596) In PDB	Homo sapiens (human)	Mam-1
4	X	DNA, HES1 promoter	polymer	37	11526.5	1
5	Y	DNA, HES1 promoter	polymer	37	11211.2	1

Sequence modifications

A, D: 9 - 434 (UniProt: Q06330)

PDB	External Database	Details
Met 8	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag

B, E: 1873 - 2127 (UniProt: P46531)

PDB	External Database	Details
Gly 1872	-	expression tag

C, F: 13 - 74 (UniProt: Q92585)

PDB	External Database	Details
Gly 12	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	192047.6
All*	Total formula weight	192047.6

*Water molecules are not included.